ArticleThe American journal of pathology2003
Chemokine production and leukocyte recruitment to the lungs of Paracoccidioides brasiliensis-infected mice is modulated by interferon-gamma.
Article in The American journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 74 citations in OpenAlex.
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- Invariant Natural Killer T Cells as Key Players in Host Resistance againstJournal of immunology research · 2021Article
- β2 Integrin-Mediated Susceptibility toFrontiers in cellular and infection microbiology · 2021Article
- Chronic mucocutaneous candidiasis associated with paracoccidioidomycosis in a patient with mannose receptor deficiency: First case reported in the literature.Revista da Sociedade Brasileira de Medicina Tropical · 2021Article
- Reconstituting NK Cells After Allogeneic Stem Cell Transplantation Show Impaired Response to the Fungal PathogenFrontiers in immunology · 2020Article
- Proteomic Analysis ofFrontiers in microbiology · 2019Article
- Disease progression in mice exposed to low-doses of aerosolized clinical isolates of Burkholderia pseudomallei.PloS one · 2018Article
- Insulin ModulatesJournal of diabetes research · 2018Article
- Functional and phenotypic evaluation of eosinophils from patients with the acute form of paracoccidioidomycosis.PLoS neglected tropical diseases · 2017Article
- Tolerogenic Plasmacytoid Dendritic Cells Control Paracoccidioides brasiliensis Infection by Inducting Regulatory T Cells in an IDO-Dependent Manner.PLoS pathogens · 2016Article
- Depletion of Neutrophils Exacerbates the Early Inflammatory Immune Response in Lungs of Mice Infected with Paracoccidioides brasiliensis.Mediators of inflammation · 2016Article
- Resistance to P. brasiliensis Experimental Infection of Inbred Mice Is Associated with an Efficient Neutrophil Mobilization and Activation by Mediators of Inflammation.Mediators of inflammation · 2015Article
- Neutrophil Extracellular Traps Identification in Tegumentary Lesions of Patients with Paracoccidioidomycosis and Different Patterns of NETs Generation In Vitro.PLoS neglected tropical diseases · 2015Article
- Pentoxifylline immunomodulation in the treatment of experimental chronic pulmonary paracoccidioidomycosis.Fibrogenesis & tissue repair · 2015Article
- Saccharomyces cerevisiae expressing Gp43 protects mice against Paracoccidioides brasiliensis infection.PloS one · 2015Article
- Traffic of leukocytes and cytokine up-regulation in the central nervous system in a murine model of neuroparacoccidioidomycosis.Mycopathologia · 2013Article
- 5-Lipoxygenase activity increases susceptibility to experimental Paracoccidioides brasiliensis infection.Infection and immunity · 2013Article
- The pivotal role of 5-lipoxygenase-derived LTB4 in controlling pulmonary paracoccidioidomycosis.PLoS neglected tropical diseases · 2013Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemokines and chemokine receptors play a role in cell recruitment during granulomatous inflammatory reactions. Here, we evaluated the expression of chemokines and chemokine receptors and their regulation by IFN-gamma in the course of Paracoccidioides brasiliensis (Pb) infection in mice. We found an association between KC and MIP-1alpha (CCL3) production and neutrophil infiltration in the lungs of Pb-infected mice during the early acute phase of infection. High levels of RANTES/CCL5, MCP-1/CCL2, IP-10/CXCL10, and Mig/CXCL9 simultaneously with mononuclear cell infiltration in the lungs was found. In the absence of IFN-gamma (GKO mice) we observed increased production of KC and MIP-1alpha and chronic neutrophilia. Moreover, we found a change in the chemokine receptor profiles expressed by wild-type (WT) versus GKO animals. Increased expression of CXCR3 and CCR5, and low levels of CCR3 and CCR4 were observed in the lungs of Pb-infected WT mice, whereas the opposite effect was observed in the lungs of GKO mice. Consistent with these results, infected cells from WT mice preferentially migrated in response to IP-10 (CXCR3 ligand), while those from GKO mice migrated in response to eotaxin/CCL11 (CCR3 ligand). These results suggest that IFN-gamma modulates the expression of chemokines and chemokine receptors as well as the kind of cells that infiltrate the lungs of Pb-infected mice.
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