ArticleThe American journal of pathology2003
Temporal and spatial patterns of expression of inhibitors of apoptosis in human placentas.
Article in The American journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 68 citations in OpenAlex.
- Effects of early pregnancy on NOD-like receptor expression in the ovine endometrium.Frontiers in veterinary science · 2024Article
- Changes in expression levels of Nod-like receptors in the spleen of ewes.Animal reproduction · 2023Article
- Early Pregnancy Modulates Expression of the Nod-like Receptor Family in Lymph Nodes of Ewes.Animals : an open access journal from MDPI · 2022Article
- Article
- Inhibitors of apoptosis: expression and regulation in the endometrium during the estrous cycle and at the maternal-conceptus interface during pregnancy in pigs.Animal bioscience · 2022Article
- Apelin, APJ, and ELABELA: Role in Placental Function, Pregnancy, and Foetal Development-An Overview.Cells · 2021Review
- Hypoxia-Induced Alpha-Globin Expression in Syncytiotrophoblasts Mimics the Pattern Observed in Preeclamptic Placentas.International journal of molecular sciences · 2021Article
- Targeting EpCAM by a Bispecific Trifunctional Antibody Exerts Profound Cytotoxic Efficacy in Germ Cell Tumor Cell Lines.Cancers · 2020Article
- Therapeutic Potency of Nanoformulations of siRNAs and shRNAs in Animal Models of Cancers.Pharmaceutics · 2018Review
- Characterization of apoptosis and autophagy through Bcl-2 and Beclin-1 immunoexpression in gestational trophoblastic disease.Iranian journal of reproductive medicine · 2015Article
- Preeclampsia is associated with alterations in the p53-pathway in villous trophoblast.PloS one · 2014Article
- Function of survivin in trophoblastic cells of the placenta.PloS one · 2013Article
- Increased resistance to apoptosis during differentiation and syncytialization of BeWo choriocarcinoma cells.Advances in bioscience and biotechnology (Print) · 2012Article
- AKT controls human first trimester trophoblast cell sensitivity to FAS-mediated apoptosis by regulating XIAP expression.Biology of reproduction · 2010Article
- Protein tyrosine phosphatase interacting protein 51 (PTPIP51) mRNA expression and localization and its in vitro interacting partner protein tyrosine phosphatase 1B (PTP1B) in human placenta of the first, second, and third trimester.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2009Article
- Double inhibition of XIAP and Bcl-2 axis is beneficial for retrieving sensitivity of renal cell cancer to apoptosis.British journal of cancer · 2008Article
- Livin and Bcl-2 expression in high-grade osteosarcoma.Journal of cancer research and clinical oncology · 2008Article
- The tumor gene survivin is highly expressed in adult renal tubular cells: implications for a pathophysiological role in the kidney.The American journal of pathology · 2007Article
- Role of the Survivin gene in pathophysiology.The American journal of pathology · 2006Review
- Soluble receptor (DcR3) and cellular inhibitor of apoptosis-2 (cIAP-2) protect human cytotrophoblast cells against LIGHT-mediated apoptosis.The American journal of pathology · 2004Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The apoptosis cascade that plays a central role in normal and pathological processes is strictly controlled, in part by newly described members of the inhibitor of apoptosis (IAP) family (HIAP-1, HIAP-2, XIAP, NAIP, Survivin, and Livin). Here, we report the expression of IAP mRNAs and proteins in early and late gestation human placentas, term cytotrophoblast cells, and two choriocarcinoma cell lines, JEG-3 and Jar. Reverse transcriptase-polymerase chain reaction identified mRNAs derived from all of the currently known IAP genes in all samples. Analysis by immunoblotting revealed that IAP proteins are present in early and late gestation human placentas and that levels of IAPs are not identical in normal and transformed trophoblast cells. Immunohistochemical experiments performed on paraformaldehyde-fixed tissue sections taken from early and late stages of pregnancy demonstrated that expression patterns differed according to cell lineage and stage of cell differentiation. The results of this study are consistent with the postulate that IAP proteins have critical roles in placental cell survival and suggest that specific apoptosis inhibitors may protect normal and transformed trophoblast cells from cell death.
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