ArticleThe American journal of pathology2003
Hypermethylation of the RUNX3 gene promoter in testicular yolk sac tumor of infants.
Article in The American journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Hepatic Yolk Sac Tumor: A Systematic Review of Presentation, Diagnosis, and Treatment.Journal of gastrointestinal cancer · 2025Pooled it
- 46,XX pure gonadal dysgenesis presenting with a massive yolk sac tumor: a diagnostic and surgical challenge - a rare case report.Annals of medicine and surgery (2012) · 2026Article
- Molecular pathology of testicular germ cell tumours: an update for practicing pathologists.Histopathology · 2026Review
- Yolk sac tumor of the liver in an infant: A case report.Radiology case reports · 2024Article
- Comparison of clinical characteristics of testicular tumor between children and adult population: a retrospective analysis.BMC cancer · 2024Article
- Subtle Presentation of Two Rare Gynecological Cancers in a Single Patient: A Case Report.Cureus · 2024Article
- Case Report: Primary endodermal sinus tumor on the abdominal wall near the right liver: a diagnostic pitfall.Frontiers in oncology · 2023Article
- Review
- Human Germ Cell Tumors are Developmental Cancers: Impact of Epigenetics on Pathobiology and Clinic.International journal of molecular sciences · 2019Review
- Epigenetic inactivation ofAnnals of surgical treatment and research · 2018Article
- Runx3 is a key modulator during the epithelial-mesenchymal transition of alveolar type II cells in animal models of BPD.International journal of molecular medicine · 2017Article
- Investigation of methylation and protein expression of theBiomedical reports · 2015Article
- A very unusual complication of amniocentesis.Clinical case reports · 2015Article
- Genome wide DNA methylation profiles provide clues to the origin and pathogenesis of germ cell tumors.PloS one · 2015Article
- CpG-oligodeoxynucleotides suppress the proliferation of A549 lung adenocarcinoma cells via toll-like receptor 9 signaling and upregulation of Runt-related transcription factor 3 expression.Biomedical reports · 2014Article
- DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors.BMC cancer · 2013Article
- Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer.Oncogene · 2010Article
- Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.The Journal of biological chemistry · 2010Article
- Yolk sac tumor but not seminoma or teratoma is associated with abnormal epigenetic reprogramming pathway and shows frequent hypermethylation of various tumor suppressor genes.Cancer science · 2009Article
- Evaluation of 1p36 markers and clinical outcome in a skull base chordoma study.Neuro-oncology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Testicular yolk sac tumor (YST) of infants is biologically distinct from its adult counterpart. Cytogenetically, YSTs in infants generally lack i(12p), which is highly characteristic of adult germ cell tumors (GCTs), whereas they frequently show a deletion of 1p36, indicating that the loss of a certain gene(s) in this region is an important event in the pathogenesis of infantile YSTs. In the present study, we examined 10 testicular YSTs from infants for promoter methylation status of the RUNX3 gene, localizing in 1p36.1, and loss of heterozygosity (LOH) in this region, on the presumption that RUNX3 acts as a tumor suppressor. Methylation of RUNX3 and LOH at 1p36.1 were detected in 8 of 10 (80%) and 6 of 8 (75%) infantile YSTs examined, respectively. All six cases harboring LOH showed RUNX3 methylation. In contrast, 0 of 12 adult GCTs showed RUNX3 methylation, and LOH at 1p36.1 was less frequent (1 of 6 cases: 16%) in adult GCTs. There is a significant difference in RUNX3 methylation between these 2 groups (P < 0.001). In normal testes of the young group, RUNX3 methylation was not detected. These results strongly suggest that RUNX3 is one of the tumor suppressors involved in the pathogenesis of testicular YSTs in infants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.