ArticleJournal of molecular biology2003
Memory in retroviral quasispecies: experimental evidence and theoretical model for human immunodeficiency virus.
Article in Journal of molecular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Genetic diversity accelerates canine distemper virus adaptation to ferrets.Journal of virology · 2024Article
- Cellular and Natural Viral Engineering in Cognition-Based Evolution.Communicative & integrative biology · 2023Review
- Standing Genetic Diversity and Transmission Bottleneck Size Drive Adaptation in Bacteriophage Qβ.International journal of molecular sciences · 2022Article
- Viral quasispecies.PLoS genetics · 2019Article
- Article
- Review
- Biased mutational pattern and quasispecies hypothesis in H5N1 virus.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2013Article
- Drug-related mutational patterns in hepatitis B virus (HBV) reverse transcriptase proteins from Iranian treatment-naïve chronic HBV patients.Hepatitis monthly · 2013Article
- Viral quasispecies evolution.Microbiology and molecular biology reviews : MMBR · 2012Review
- Genetic characterization of hepatitis B virus in peripheral blood leukocytes: evidence for selection and compartmentalization of viral variants with the immune escape G145R mutation.Journal of virology · 2009Article
- Arenavirus genetic diversity and its biological implications.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2009Review
- Quasispecies and its impact on viral hepatitis.Virus research · 2007Review
- Emergence of mammalian cell-adapted vesicular stomatitis virus from persistent infections of insect vector cells.Journal of virology · 2007Article
- Hepatitis C virus infection--pathobiology and implications for new therapeutic options.Digestive diseases and sciences · 2007Review
- Fitness landscape of human immunodeficiency virus type 1 protease quasispecies.Journal of virology · 2007Article
- Viruses as quasispecies: biological implications.Current topics in microbiology and immunology · 2006Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viral quasispecies may possess a molecular memory of their past evolutionary history, imprinted on minority components of the mutant spectrum. Here we report experimental evidence and a theoretical model for memory in retroviral quasispecies in vivo. Apart from replicative memory associated with quasispecies dynamics, retroviruses may harbour a "cellular" or "anatomical" memory derived from their integrative cycle and the presence of viral reservoirs in body compartments. Three independent sets of data exemplify the two kinds of memory in human immunodeficiency virus type 1 (HIV-1). The data provide evidence of re-emergence of sequences that were hidden in cellular or anatomical compartments for extended periods of infection, and recovery of a quasispecies from pre-existing genomes. We develop a three-component model that incorporates the essential features of the quasispecies dynamics of retroviruses exposed to selective pressures. Significantly, a numerical study based on this model is in agreement with the experimental data, further supporting the existence of both replicative and reservoir memory in retroviral quasispecies.
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