ArticleReproductive biology and endocrinology : RB&E2003
Nitric oxide synthase activity in human trophoblast, term placenta and pregnant myometrium.
Article in Reproductive biology and endocrinology : RB&E, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Prenatal anemia and postpartum hemorrhage risk: A systematic review and meta-analysis.The journal of obstetrics and gynaecology research · 2021Pooled it
- Antenatal Intravenous Iron Therapy in Anemic Pregnancies: Associations with Obstetric Patient Blood Management and Neonatal Outcomes.Nutrients · 2026Observational
- Early Placental Angioactive Response to Maternal SARS-CoV-2 Infection: an Immunohistochemical Study.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Supplementation with hArg During the Rapid Growth of the Placenta Modulates Final Placental Angiogenesis and Pregnancy Outcomes.Nutrients · 2025Article
- Anemia during pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis of cohort studies.Frontiers in global women's health · 2025Review
- Impact of anemia and thrombocytopenia on postpartum hemorrhage risk among women with term singleton pregnancy.Journal of thrombosis and thrombolysis · 2023Article
- SARS- CoV-2 infection and oxidative stress in early-onset preeclampsia.Biochimica et biophysica acta. Molecular basis of disease · 2022Review
- Tianma Gouteng Decoction Exerts Pregnancy-Protective Effects Against PreeclampsiaFrontiers in pharmacology · 2022Article
- Anandamide Exerts a Differential Effect on Human Placenta Before and After the Onset of Labor.Frontiers in physiology · 2021Article
- Effect of prematurity on genome wide methylation in the placenta.BMC medical genetics · 2019Article
- Crosstalk Between Nitric Oxide and Endocannabinoid Signaling Pathways in Normal and Pathological Placentation.Frontiers in physiology · 2018Review
- Protective effect of (±)α-tocopherol on brominated diphenyl ether-47-stimulated prostaglandin pathways in human extravillous trophoblasts in vitro.Toxicology in vitro : an international journal published in association with BIBRA · 2015Article
- Review
- Vasodilator factors in the systemic and local adaptations to pregnancy.Reproductive biology and endocrinology : RB&E · 2009Review
- Does nitric oxide play a role in maternal tolerance towards the foetus?Journal of physiology and biochemistry · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the possible role of nitric oxide (NO) produced locally or intramurally in the quiescence of the pregnant myometrium, nitric oxide synthase (NOS) activity was measured in samples from first trimester (villous, and non villous-trophoblast), term placenta and pregnant myometrium. Trophoblast tissue was obtained from psychosocial termination of pregnancy (9-12 weeks' gestation) whereas placenta and myometrium, from the same patient, at deliveries by Caesarean section. NOS activity was measured in both cytosolic and particulate fractions by the formation of 14C-citrulline from 14C-arginine. Western immunoblotting was used to identify the endothelial NOS (eNOS) and neuronal (nNOS) isoforms. The activity of NOS in particulate fractions from all preparations was considerably higher than the cytosolic fractions. Activity in all fractions except the myometrium was highly Ca-dependent. More than 50% of particulate NOS from the myometrium was Ca-independent. NOS activity was highest in the villous trophoblast and there was a significant difference between the villous and non-villous trophoblast. In placenta and myometrium, NOS was 2-4 fold and 20-28-fold lower than the villous trophoblast, respectively. Western blot analysis showed clearly eNOS in the particulate fraction and a weak eNOS band in the cytosolic fractions, whereas nNOS was not detectable in any of the fractions. In view of the marginal activity of NOS in the myometrium, NO produced by the trophoblast and placenta could play a significant role in maintaining uterine quiescence by paracrine effect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.