SynthesisMolecular psychiatry2003
A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior.
Synthesis in Molecular psychiatry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
83 citing papers in PubMed, 7 syntheses or guidelines pooled it, 418 citations in OpenAlex.
- Suicidal risk in patients with aggression in schizophrenia: a systematic review.Frontiers in psychiatry · 2025Pooled it
- Association of the 5HTR2A gene with suicidal behavior: case-control study and updated meta-analysis.BMC psychiatry · 2013Pooled it
- Pooled it
- Meta-analysis supports association between serotonin transporter (5-HTT) and suicidal behavior.Molecular psychiatry · 2007Pooled it
- Meta-analysis reveals association between serotonin transporter gene STin2 VNTR polymorphism and schizophrenia.Molecular psychiatry · 2005Pooled it
- Meta-analysis in psychiatric genetics.Current psychiatry reports · 2005Pooled it
- A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders.Molecular psychiatry · 2003Pooled it
- Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment.Molecular psychiatry · 2009Trial
- Prevalence and clinical correlates of suicidal ideation and aggression in patients with chronic schizophrenia: large-scale, cross-sectional study.BJPsych open · 2026Article
- Beyond Latency: ChronicBiomedicines · 2025Review
- Association of HTTLPR, BDNF, and FTO Genetic Variants with Completed Suicide in Slovakia.Journal of personalized medicine · 2023Article
- The Genetic Side of the Mood: A Scientometric Review of the Genetic Basis of Mood Disorders.Genes · 2023Review
- Modeling endophenotypes of suicidal behavior in animals.Neuroscience and biobehavioral reviews · 2021Review
- Machine learning as the new approach in understanding biomarkers of suicidal behavior.Bosnian journal of basic medical sciences · 2021Review
- Impulsivity as a Risk Factor for Suicide in Bipolar Disorder.Frontiers in psychiatry · 2021Article
- Depressive Symptoms among Middle-Aged Women-Understanding the Cause.Brain sciences · 2020Article
- The impact of twenty-first century personalized medicine versus twenty-first century medicine's impact on personalization.Philosophy, ethics, and humanities in medicine : PEHM · 2020Article
- The serotonin transporter gene polymorphism (SLC6A4) and risk for psychiatric morbidity and comorbidity in the Baltimore ECA follow-up study.Comprehensive psychiatry · 2020Article
- Microsecond-timescale simulations suggest 5-HT-mediated preactivation of the 5-HTProceedings of the National Academy of Sciences of the United States of America · 2020Article
- "Out, out, brief candle! Life's but a walking shadow":Frontiers in psychiatry · 2020Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The different serotonin (5-HT) receptors, including the serotonin transporter (5-HTT), are excellent candidate genes for suicide and suicidal behavior, and thus, they have been investigated in a large number of allelic association studies. The individual results of these studies have been inconsistent and definite conclusions are difficult to establish. A reliable method for assessing individual studies and generating combined results is provided by systematic reviews using meta-analytical techniques. In this study, we carried out a systematic review of studies investigating 5-HT receptors and the 5-HTT in suicidal behavior. Studies were identified by means of MEDLINE database searches and by scanning reference lists. More than 190 articles were reviewed and 26 met the inclusion criteria. In all, 14 studies investigated six different 5-HT receptor loci and 12 studies investigated the 5-HTT promoter 44 bp insertion/deletion polymorphism. Two specific meta-analyses were carried out, pooling studies investigating the 5-HT2A 102 T/C and the 5-HTT promoter loci that included, respectively, a total of 1599 and 2539 subjects. The combined evidence was significant for association with the 5-HTT locus (Mantel-Haenszel weighted odds ratio (M-H(w) OR)=1.17 CI : 1.04-1.32, P=0.009), but not for the 5-HT2A 102 T/C variant (M-H(w) OR)=1.09 CI : 0.93-1.27, P=0.319). The 5-HTT result was robust and remained significant following sensitivity analysis, suggesting that 5-HTT may play a role in the predisposition to suicide.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.