ArticleThe Journal of experimental medicine2003
Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation.
Article in The Journal of experimental medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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Who cites it
42 citing papers in PubMed, 107 citations in OpenAlex.
- TREM2 drives monocyte-derived macrophage responses tobioRxiv : the preprint server for biology · 2026Article
- Epithelial-Immune Cell Crosstalk in Salivary Gland Tumors: Implications for Tumor Progression and Diagnostic Assessment.International journal of molecular sciences · 2025Article
- Immunoreceptor CD300a regulates ischemic tissue damage and adverse remodeling in the mouse heart and kidney.The Journal of clinical investigation · 2025Article
- CD300a: An Innate Immune Checkpoint Shaping Tumor Immunity and Therapeutic Opportunity.Cancers · 2025Review
- Mechanism of Efferocytosis in Determining Ischaemic Stroke Resolution-Diving into Microglia/Macrophage Functions and Therapeutic Modality.Molecular neurobiology · 2024Review
- Intranasal administration of ceramide liposome suppresses allergic rhinitis by targeting CD300f in murine models.Scientific reports · 2024Article
- CD300a Regulates Mouse Macrophage Functionality in Allergic Inflammation.International archives of allergy and immunology · 2023Article
- Article
- MAIR-II deficiency ameliorates cardiac remodelling post-myocardial infarction by suppressing TLR9-mediated macrophage activation.Journal of cellular and molecular medicine · 2020Article
- Weighted gene co-expression network analysis identified underlying hub genes and mechanisms in the occurrence and development of viral myocarditis.Annals of translational medicine · 2020Article
- The Expression and Function of CD300 Molecules in the Main Players of Allergic Responses: Mast Cells, Basophils and Eosinophils.International journal of molecular sciences · 2020Review
- Leukocyte mono-immunoglobulin-like receptor 8 (LMIR8)/CLM-6 is an FcRγ-coupled receptor selectively expressed in mouse tissue plasmacytoid dendritic cells.Scientific reports · 2018Article
- The CD300e molecule in mice is an immune-activating receptor.The Journal of biological chemistry · 2018Article
- A CD300c-Fc Fusion Protein Inhibits T Cell Immunity.Frontiers in immunology · 2018Article
- Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment.Scientific reports · 2017Article
- Ceramide-CD300f Binding Inhibits Lipopolysaccharide-induced Skin Inflammation.The Journal of biological chemistry · 2017Article
- Recent advances in understanding noroviruses.F1000Research · 2017Review
- Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces.Nature immunology · 2016Article
- Identification and Characterization of CD300H, a New Member of the Human CD300 Immunoreceptor Family.The Journal of biological chemistry · 2015Article
- Tie2 Signaling Enhances Mast Cell Progenitor Adhesion to Vascular Cell Adhesion Molecule-1 (VCAM-1) through α4β1 Integrin.PloS one · 2015Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immune responses are regulated by opposing positive and negative signals triggered by the interaction of activating and inhibitory cell surface receptors with their ligands. Here, we describe novel paired activating and inhibitory immunoglobulin-like receptors, designated myeloid-associated immunoglobulin-like receptor (MAIR) I and MAIR-II, whose extracellular domains are highly conserved by each other. MAIR-I, expressed on the majority of myeloid cells, including macrophages, granulocytes, mast cells, and dendritic cells, contains the tyrosine-based sorting motif and the immunoreceptor tyrosine-based inhibitory motif-like sequences in the cytoplasmic domain and mediates endocytosis of the receptor and inhibition of IgE-mediated degranulation from mast cells. On the other hand, MAIR-II, expressed on subsets of peritoneal macrophages and B cells, associates with the immunoreceptor tyrosine-based activation motif-bearing adaptor DAP12 and stimulates proinflammatory cytokines and chemokine secretions from macrophages. Thus, MAIR-I and MAIR-II play important regulatory roles in cell signaling and immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.