ArticleGenetics2003
Locus-specific genetic differentiation at Rw among warfarin-resistant rat (Rattus norvegicus) populations.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 45 citations in OpenAlex.
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- Towards the identification of the loci of adaptive evolution.Methods in ecology and evolution · 2015Review
- On the stability of the Bayenv method in assessing human SNP-environment associations.Human genomics · 2014Article
- Effects of freshwater pollution on the genetics of zebra mussels (Dreissena polymorpha) at the molecular and population level.BioMed research international · 2014Article
- Linkage disequilibrium and genome-wide association mapping in tetraploid wheat (Triticum turgidum L.).PloS one · 2014Article
- Mitochondrial DNA phylogeography of the Norway rat.PloS one · 2014Article
- Positive selection in the chromosome 16 VKORC1 genomic region has contributed to the variability of anticoagulant response in humans.PloS one · 2012Article
- Article
- Genomic approaches with natural fish populations.Journal of fish biology · 2010Review
- A cardiovascular phenotype in warfarin-resistant Vkorc1 mutant rats.Artery research · 2008Article
- Signatures of selection in natural populations adapted to chronic pollution.BMC evolutionary biology · 2008Article
- Selective sweeps reveal candidate genes for adaptation to drought and salt tolerance in common sunflower, Helianthus annuus.Genetics · 2007Article
- Selective sweep mapping of genes with large phenotypic effects.Genome research · 2005Article
- High-diversity genes in the Arabidopsis genome.Genetics · 2005Article
- Pharmacogenetics and anticoagulant therapy.Journal of thrombosis and thrombolysisReview
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Populations may diverge at fitness-related genes as a result of adaptation to local conditions. The ability to detect this divergence by marker-based genomic scans depends on the relative magnitudes of selection, recombination, and migration. We survey rat (Rattus norvegicus) populations to assess the effect that local selection with anticoagulant rodenticides has had on microsatellite marker variation and differentiation at the warfarin resistance gene (Rw) relative to the effect on the genomic background. Initially, using a small sample of 16 rats, we demonstrate tight linkage of microsatellite D1Rat219 to Rw by association mapping of genotypes expressing an anticoagulant-rodenticide-insensitive vitamin K 2,3-epoxide reductase (VKOR). Then, using allele frequencies at D1Rat219, we show that predicted and observed resistance levels in 27 populations correspond, suggesting intense and recent selection for resistance. A contrast of F(ST) values between D1Rat219 and the genomic background revealed that rodenticide selection has overwhelmed drift-mediated population structure only at Rw. A case-controlled design distinguished these locus-specific effects of selection at Rw from background levels of differentiation more effectively than a population-controlled approach. Our results support the notion that an analysis of locus-specific population genetic structure may assist the discovery and mapping of novel candidate loci that are the object of selection or may provide supporting evidence for previously identified loci.
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