ArticleGenetics2003
Theory of the effects of population structure and sampling on patterns of linkage disequilibrium applied to genomic data from humans.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Article
- The Linkage-Disequilibrium and Recombinational Landscape in Daphnia pulex.Genome biology and evolution · 2022Article
- Properties of 2-locus genealogies and linkage disequilibrium in temporally structured samples.Genetics · 2022Article
- Article
- The evolution of selfing is accompanied by reduced efficacy of selection and purging of deleterious mutations.Genetics · 2015Article
- Inference of the properties of the recombination process from whole bacterial genomes.Genetics · 2014Article
- Article
- Investigating sex-specific dynamics using uniparental markers: West New Guinea as a case study.Ecology and evolution · 2013Article
- The effects of linkage and gene flow on local adaptation: a two-locus continent-island model.Theoretical population biology · 2011Article
- Boechera, a model system for ecological genomics.Molecular ecology · 2011Review
- Haplotype structure and divergence at human and chimpanzee serotonin transporter and receptor genes: implications for behavioral disorder association analyses.Molecular biology and evolution · 2010Article
- Mating-system variation, demographic history and patterns of nucleotide diversity in the Tristylous plant Eichhornia paniculata.Genetics · 2010Article
- Variation in genetic admixture and population structure among Latinos: the Los Angeles Latino eye study (LALES).BMC genetics · 2009Article
- The impact of sampling schemes on the site frequency spectrum in nonequilibrium subdivided populations.Genetics · 2009Article
- Fundamental concepts in genetics: effective population size and patterns of molecular evolution and variation.Nature reviews. Genetics · 2009Review
- Stepping-stone spatial structure causes slow decay of linkage disequilibrium and shifts the site frequency spectrum.Genetics · 2007Article
- Article
- Microsatellite diversity and broad scale geographic structure in a model legume: building a set of nested core collection for studying naturally occurring variation in Medicago truncatula.BMC plant biology · 2006Article
- Impact of mating systems on patterns of sequence polymorphism in flowering plants.Proceedings. Biological sciences · 2006Article
- Linkage disequilibrium between incompatibility locus region genes in the plant Arabidopsis lyrata.Genetics · 2006Article
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2 authors.
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Abstract
We develop predictions for the correlation of heterozygosity and for linkage disequilibrium between two loci using a simple model of population structure that includes migration among local populations, or demes. We compare the results for a sample of size two from the same deme (a single-deme sample) to those for a sample of size two from two different demes (a scattered sample). The correlation in heterozygosity for a scattered sample is surprisingly insensitive to both the migration rate and the number of demes. In contrast, the correlation in heterozygosity for a single-deme sample is sensitive to both, and the effect of an increase in the number of demes is qualitatively similar to that of a decrease in the migration rate: both increase the correlation in heterozygosity. These same conclusions hold for a commonly used measure of linkage disequilibrium (r(2)). We compare the predictions of the theory to genomic data from humans and show that subdivision might account for a substantial portion of the genetic associations observed within the human genome, even though migration rates among local populations of humans are relatively large. Because correlations due to subdivision rather than to physical linkage can be large even in a single-deme sample, then if long-term migration has been important in shaping patterns of human polymorphism, the common practice of disease mapping using linkage disequilibrium in "isolated" local populations may be subject to error.
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