ArticleGenetics2003
Rapid, selective digestion of mitochondrial DNA in accordance with the matA hierarchy of multiallelic mating types in the mitochondrial inheritance of Physarum polycephalum.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 57 citations in OpenAlex.
- Evolution and maintenance of mtDNA gene content across eukaryotes.The Biochemical journal · 2024Review
- Diet and mitonuclear haplotype interactions affect growth rate in a slime mould.Ecology and evolution · 2023Article
- G × G × E effect on phenotype expression in a non-conventional model organism, the unicellular slime mouldBiology letters · 2023Article
- Semi-in vitro detection of MgScientific reports · 2022Article
- Mitochondrial genome and diverse inheritance patterns in Pleurotus pulmonarius.Journal of microbiology (Seoul, Korea) · 2020Article
- Selfish Mitonuclear Conflict.Current biology : CB · 2019Review
- Malaria parasites of long-tailed macaques in Sarawak, Malaysian Borneo: a novel species and demographic and evolutionary histories.BMC evolutionary biology · 2018Article
- Uniparental Inheritance Promotes Adaptive Evolution in Cytoplasmic Genomes.Molecular biology and evolution · 2017Article
- Selection against heteroplasmy explains the evolution of uniparental inheritance of mitochondria.PLoS genetics · 2015Article
- Review of cytological studies on cellular and molecular mechanisms of uniparental (maternal or paternal) inheritance of plastid and mitochondrial genomes induced by active digestion of organelle nuclei (nucleoids).Journal of plant research · 2010Review
- Uniparental inheritance of cpDNA and the genetic control of sexual differentiation in Chlamydomonas reinhardtii.Journal of plant research · 2010Review
- Mitochondrial fusion and inheritance of the mitochondrial genome.Journal of plant research · 2010Review
- Cytoplasmic inheritance in green algae: patterns, mechanisms and relation to sex type.Journal of plant research · 2010Review
- Maternal inheritance of mitochondria: multipolarity, multiallelism and hierarchical transmission of mitochondrial DNA in the true slime mold Physarum polycephalum.Journal of plant research · 2010Review
- Mechanisms of organelle division and inheritance and their implications regarding the origin of eukaryotic cells.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2010Review
- Article
- The mating type-specific homeodomain genes SXI1 alpha and SXI2a coordinately control uniparental mitochondrial inheritance in Cryptococcus neoformans.Current genetics · 2007Article
- Active digestion of sperm mitochondrial DNA in single living sperm revealed by optical tweezers.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Early zygote-specific nuclease in mitochondria of the true slime mold Physarum polycephalum.Current genetics · 2005Article
- Rearrangements in the Physarum polycephalum mitochondrial genome associated with a transition from linear mF-mtDNA recombinants to circular molecules.Current genetics · 2005Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although mitochondria are inherited uniparentally in nearly all eukaryotes, the mechanism for this is unclear. When zygotes of the isogamous protist Physarum polycephalum were stained with DAPI, the fluorescence of mtDNA in half of the mitochondria decreased simultaneously to give small spots and then disappeared completely approximately 1.5 hr after nuclear fusion, while the other mitochondrial nucleoids and all of the mitochondrial sheaths remained unchanged. PCR analysis of single zygote cells confirmed that the loss was limited to mtDNA from one parent. The vacant mitochondrial sheaths were gradually eliminated by 60 hr after mating. Using six mating types, the transmission patterns of mtDNA were examined in all possible crosses. In 39 of 60 crosses, strict uniparental inheritance was confirmed in accordance with a hierarchy of relative sexuality. In the other crosses, however, mtDNA from both parents was transmitted to plasmodia. The ratio of parental mtDNA was estimated to be from 1:1 to 1:10(-4). Nevertheless, the matA hierarchy was followed. In these crosses, the mtDNA was incompletely digested, and mtDNA replicated during subsequent plasmodial development. We conclude that the rapid, selective digestion of mtDNA promotes the uniparental inheritance of mitochondria; when this fails, biparental inheritance occurs.
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