ArticleGenetics2003
Telomerase-independent proliferation is influenced by cell type in Saccharomyces cerevisiae.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence.Nature structural & molecular biology · 2013Article
- Multiple genetic pathways regulate replicative senescence in telomerase-deficient yeast.Aging cell · 2013Article
- Saccharomyces cerevisiae as a Model to Study Replicative Senescence Triggered by Telomere Shortening.Frontiers in oncology · 2013Article
- Deregulated telomere transcription causes replication-dependent telomere shortening and promotes cellular senescence.Nucleic acids research · 2012Article
- Reversibility of replicative senescence in Saccharomyces cerevisiae: effect of homologous recombination and cell cycle checkpoints.DNA repair · 2012Article
- Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction.The EMBO journal · 2010Article
- Mating type influences chromosome loss and replicative senescence in telomerase-deficient budding yeast by Dnl4-dependent telomere fusion.Molecular microbiology · 2008Article
- Article
- Mdt1 facilitates efficient repair of blocked DNA double-strand breaks and recombinational maintenance of telomeres.Molecular and cellular biology · 2007Article
- Control of the yeast telomeric senescence survival pathways of recombination by the Mec1 and Mec3 DNA damage sensors and RPA.Nucleic acids research · 2007Article
- Different mating-type-regulated genes affect the DNA repair defects of Saccharomyces RAD51, RAD52 and RAD55 mutants.Genetics · 2006Article
- Telomerase-independent stabilization of short telomeres in Trypanosoma brucei.Molecular and cellular biology · 2006Article
- Making the most of a little: dosage effects in eukaryotic telomere length maintenance.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2005Review
- Telomere cap components influence the rate of senescence in telomerase-deficient yeast cells.Molecular and cellular biology · 2004Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Yeast strains harboring mutations in genes required for telomerase function (TLC1 and the EST genes) exhibit progressive shortening of telomeric DNA and replicative senescence. A minority of cells withstands loss of telomerase through RAD52-dependent amplification of telomeric and subtelomeric sequences; such survivors are now capable of long-term propagation with telomeres maintained by recombination rather than by telomerase. Here we report that simultaneous expression in haploid cells of both MATa and MATalpha information suppresses the senescence of telomerase-deficient mutants, with suppression occurring via the RAD52-dependent survivor pathway(s). Such suppression can be mimicked by deletion of SIR1-SIR4, genes that function in transcriptional silencing of several loci including the silent mating-type loci. Furthermore, telomerase-defective diploid strains that express only MATa or MATalpha information senesce at a faster rate than telomerase-defective diploids that are heterozygous at the MAT locus. This suggests that the RAD52-dependent pathway(s) for telomere maintenance respond to changes in the levels of recombination, a process regulated in part by the hierarchy of gene control that includes MAT regulation. We propose that cell-type-specific regulation of recombination at human telomeres may similarly contribute to the tissue-specific patterns of disease found in telomerase-deficient tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.