ArticleGenetics2003
Genetic interactions with CLF1 identify additional pre-mRNA splicing factors and a link between activators of yeast vesicular transport and splicing.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 48 citations in OpenAlex.
- Binding by calmodulin is coupled to transient unfolding of the third FF domain of Prp40A.Protein science : a publication of the Protein Society · 2023Article
- AtfA-Independent Adaptation to the Toxic Heavy Metal Cadmium inMicroorganisms · 2021Article
- A Cyclophilin OsCYP20-2 Interacts with OsSYF2 to Regulate Grain Length by Pre-mRNA Splicing.Rice (New York, N.Y.) · 2020Article
- Overexpression of SYF2 promotes cell proliferation and correlates with poor prognosis in human breast cancer.Oncotarget · 2017Article
- Overexpression of SYF2 correlates with enhanced cell growth and poor prognosis in human hepatocellular carcinoma.Molecular and cellular biochemistry · 2015Article
- SYF2 is upregulated in human epithelial ovarian cancer and promotes cell proliferation.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Upregulation of SYF2 Relates to Retinal Ganglion Cell Apoptosis and Retinal Glia Cell Proliferation After Light-Induced Retinal Damage.Journal of molecular neuroscience : MN · 2015Article
- Structural requirement of Ntc77 for spliceosome activation and first catalytic step.Nucleic acids research · 2014Article
- Upregulation of SYF2 in esophageal squamous cell carcinoma promotes tumor cell proliferation and predicts poor prognosis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Knocking down the expression of SYF2 inhibits the proliferation of glioma cells.Medical oncology (Northwood, London, England) · 2014Article
- Cell morphogenesis proteins are translationally controlled through UTRs by the Ndr/LATS target Ssd1.PloS one · 2014Article
- Malleable ribonucleoprotein machine: protein intrinsic disorder in the Saccharomyces cerevisiae spliceosome.PeerJ · 2013Article
- Disruption of murine mp29/Syf2/Ntc31 gene results in embryonic lethality with aberrant checkpoint response.PloS one · 2012Article
- The Caenorhabditis elegans gene mfap-1 encodes a nuclear protein that affects alternative splicing.PLoS genetics · 2012Article
- Article
- Cbk1 regulation of the RNA-binding protein Ssd1 integrates cell fate with translational control.Current biology : CB · 2009Article
- A systematic characterization of Cwc21, the yeast ortholog of the human spliceosomal protein SRm300.RNA (New York, N.Y.) · 2009Article
- Spp382p interacts with multiple yeast splicing factors, including possible regulators of Prp43 DExD/H-Box protein function.Genetics · 2009Article
- A structural model for the HAT domain of Utp6 incorporating bioinformatics and genetics.Protein engineering, design & selection : PEDS · 2009Article
- A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing.Molecular and cellular biology · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Clf1 is a conserved spliceosome assembly factor composed predominately of TPR repeats. Here we show that the TPR elements are not functionally equivalent, with the amino terminus of Clf1 being especially sensitive to change. Deletion and add-back experiments reveal that the splicing defect associated with TPR removal results from the loss of TPR-specific sequence information. Twelve mutants were found that show synthetic growth defects when combined with an allele that lacks TPR2 (i.e., clf1Delta2). The identified genes encode the Mud2, Ntc20, Prp16, Prp17, Prp19, Prp22, and Syf2 splicing factors and four proteins without established contribution to splicing (Bud13, Cet1, Cwc2, and Rds3). Each synthetic lethal with clf1Delta2 (slc) mutant is splicing defective in a wild-type CLF1 background. In addition to the splicing factors, SSD1, BTS1, and BET4 were identified as dosage suppressors of clf1Delta2 or selected slc mutants. These results support Clf1 function through multiple stages of the spliceosome cycle, identify additional genes that promote cellular mRNA maturation, and reveal a link between Rab/Ras GTPase activation and the process of pre-mRNA splicing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.