ReviewBritish journal of pharmacology2003
Muscarinic regulation of cardiac ion channels.
Review in British journal of pharmacology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 173 citations in OpenAlex.
- Which antimuscarinic agents used in the treatment of overactive bladder increase heart rate? a prospective randomized clinical trial.International urology and nephrology · 2019Trial
- Guidelines for rigor and reproducibility of heart rate variability within human cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2026Review
- Development of a double-pharmacophore workflow for screening subtype-selective MMolecular diversity · 2026Article
- Glial cells in the heart: Implications for their roles in health and disease.The Journal of physiology · 2026Review
- Autonomic imbalance in cardiovascular disease: molecular mechanisms and emerging therapeutics.American journal of physiology. Cell physiology · 2025Review
- Nonlinear high-activity neuronal excitation enhances odor discrimination.Current biology : CB · 2025Article
- Spatiotemporal profiling of protein kinase A activity in spontaneously beating hiPSC-derived cardiac organoids.iScience · 2025Article
- Remodeling of the Intracardiac Ganglia During the Development of Cardiovascular Autonomic Dysfunction in Type 2 Diabetes: Molecular Mechanisms and Therapeutics.International journal of molecular sciences · 2024Review
- Chronic acetylcholinesterase inhibition reduces the effects of physical training on ventricular contractility and coronary bed reactivity in hypertensive rats.Scientific reports · 2024Article
- Further investigations on the influence of protein phosphatases on the signaling of muscarinic receptors in the atria of mouse hearts.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Muscarinic control of cardiovascular function in humans: a review of current clinical evidence.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Review
- Direct modulation of TRPC ion channels by Gα proteins.Frontiers in physiology · 2024Review
- Pupillometry and autonomic nervous system responses to cognitive load and false feedback: an unsupervised machine learning approach.Frontiers in neuroscience · 2024Article
- A multiscale predictive digital twin for neurocardiac modulation.The Journal of physiology · 2023Article
- Muscarinic Acetylcholine Receptors Modulate HCN Channel Properties in Vestibular Ganglion Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Autonomic Nervous System Regulation of Epicardial Adipose Tissue: Potential Roles for Regulator of G Protein Signaling-4.Current issues in molecular biology · 2022Review
- Bowel Preparation and Subsequent Colonoscopy Is Associated with the Risk of Atrial Fibrillation: A Population-Based Case-Crossover Study.Journal of personalized medicine · 2022Article
- Witches, potions, and metabolites: an overview from a medicinal perspective.RSC medicinal chemistry · 2022Review
- High-resolution structure-function mapping of intact hearts reveals altered sympathetic control of infarct border zones.JCI insight · 2022Article
- Acetylcholine Reduces IBiomedicines · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The parasympathetic component of the autonomic nervous system plays an important role in the physiological regulation of cardiac function by exerting significant influence over the initiation as well as propagation of electrical impulses, in addition to being able to regulate contractile force. These effects are mediated in whole or in part through changes in ion channel activity that occur in response to activation of M(2) muscarinic cholinergic receptors following release of the neurotransmitter acetylcholine. The coupling of M(2) receptor activation to most changes in cardiac ion channel function can be explained by one of two general paradigms. The first involves direct G protein-dependent regulation of ion channel activity. The second involves indirect regulation of ion channel activity through modulation of cAMP-dependent responses. This review focuses on recent advances in our understanding of the mechanisms by which M(2) muscarinic receptor activation both inhibits and facilitates cAMP-dependent ion channel responses in the heart.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.