ArticleKinetoplastid biology and disease2003
Apoptosis-like death in trypanosomatids: search for putative pathways and genes involved.
Article in Kinetoplastid biology and disease, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Repurposing Analysis of Nitroxoline (8-Hydroxy-5-nitroquinoline) as an Antichagasic Compound.Pharmaceuticals (Basel, Switzerland) · 2025Article
- The Potential Role of Sanguinarine as an Inhibitor of Leishmania PP2C in the Induction of Apoptosis.Acta parasitologica · 2025Article
- Identification and Characterization of Novel Serpentoviruses in Viperid and Elapid Snakes.Viruses · 2024Article
- Article
- Cell death pathways in pathogenic trypanosomatids: lessons of (over)kill.Cell death & disease · 2019Review
- VOSalophen: a vanadium complex with a stilbene derivative-induction of apoptosis, autophagy, and efficiency in experimental cutaneous leishmaniasis.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2017Article
- The first suicides: a legacy inherited by parasitic protozoans from prokaryote ancestors.Parasites & vectors · 2013Review
- Knockdown of LdMC1 and Hsp70 by antisense oligonucleotides causes cell-cycle defects and programmed cell death in Leishmania donovani.Molecular and cellular biochemistry · 2012Article
- Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death.Parasites & vectors · 2010Article
- Specific antibodies induce apoptosis in Trypanosoma cruzi epimastigotes.Parasitology research · 2010Article
- Leishmania mexicana amazonensis: plasma membrane adenine nucleotide translocator and chemotaxis.Experimental parasitology · 2008Article
- Nuclear export modulates the cytoplasmic Sir2 homologue Hst2.EMBO reports · 2006Article
- Kinetics and diagnostic and prognostic potential of quantitative Western blot analysis and antigen-specific enzyme-linked immunosorbent assay in experimental canine leishmaniasis.Clinical and vaccine immunology : CVI · 2006Article
- Experimental study of the function of the excreted/secreted Leishmania LmSIR2 protein by heterologous expression in eukaryotic cell line.Kinetoplastid biology and disease · 2005Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Members of the Trypanosomatidae family comprises species that are causative of important human diseases such as Chagas'disease, Leishmaniasis and sleeping sickness. A wealth of evidence has accumulated that illustrates the ability of these unicellular organisms to undergo, with or without induction (stress conditions), a cell death with some features resembling apoptosis-like phenomenon. However, despite the apparent phenotypic similarities between the apoptosis-like death of kinetoplastids and mammalian nucleated cell programmed cell death (PCD), the pathways seem to differ significantly. This review analyses some of the current data related to the cell death in trypanosomatids. Special attention is given to members of conserved protein families demonstrating remarkable diversity and plasticity of function [i.e. elongation factor-1 subunits alpha and gamma; and the Silent Information Regulator (SIR2)-related gene, showed to be associated with resistance to apoptosis-like death in Leishmania]. The elucidation of the molecular events which tightly regulated the processes of growth arrest, differentiation and death of Trypanosoma cruzi, Leishmania spp and African trypanosomes, might allow not only to define a more comprehensive view of the cell death machinery in term of evolutionary origin but may also be useful to identify new target molecules for chemotherapeutic drug development and therapeutic intervention.
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Registered trials
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