ArticleImmunology2003
Human secretory immunoglobulin A may contribute to biofilm formation in the gut.
Article in Immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 1 synthesis or guideline pooled it, 204 citations in OpenAlex.
- Mucosal immune response in biology, disease prevention and treatment.Signal transduction and targeted therapy · 2025Pooled it
- Effect of Endoscopic Appendix Intubation and Irrigation on Acute Uncomplicated Appendicitis.World journal of surgery · 2021Trial
- Association between bone marrow donor origin and gut microbiota composition following fecal microbiota transplantation in mice.Scientific reports · 2026Article
- Examining the role of IgA in a persistent model of Staphylococcus aureus colonization.PLoS pathogens · 2026Article
- Anti-FimA monoclonal antibodies reveal dual roles in porphyromonas gingivalis pathogenesis.Journal of oral microbiology · 2026Article
- Antibodies in breast milk: Pro-bodies designed for healthy newborn development.Immunological reviews · 2024Review
- Re-framing the importance of Group BInfection and immunity · 2024Review
- Exploring the Role of the Microbiome in Rheumatoid Arthritis-A Critical Review.Microorganisms · 2024Review
- The Clinical Relevance of an Inflamed Appendix in Crohn's Disease.Journal of Crohn's & colitis · 2024Article
- Tethering of soluble immune effectors to mucin and chitin reflects a convergent and dynamic role in gut immunity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Mitochondrial dysfunction promotes microbial composition that negatively impacts on ulcerative colitis development and progression.NPJ biofilms and microbiomes · 2023Article
- The appendix and ulcerative colitis - an unsolved connection.Nature reviews. Gastroenterology & hepatology · 2023Review
- IgA Determines Bacterial Composition in the Gut.Crohn's & colitis 360 · 2023Article
- Appendix and Ulcerative Colitis: a Key to Explaining the Pathogenesis and Directing Novel Therapies?Inflammatory bowel diseases · 2023Review
- Enhanced Th17 responses in the appendix of children with complex compared to simple appendicitis are associated with microbial dysbiosis.Frontiers in immunology · 2023Article
- The Mechanism of Important Components in Canine Fecal Microbiota Transplantation.Veterinary sciences · 2022Review
- Gut microbiota: a new avenue to reveal pathological mechanisms of constipation.Applied microbiology and biotechnology · 2022Review
- Disaggregation as an interaction mechanism among intestinal bacteria.Biophysical journal · 2022Article
- Changes in intestinal homeostasis and immunity in a cigarette smoke- and LPS-induced murine model for COPD: the lung-gut axis.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- Gut microbiome and breast-feeding: Implications for early immune development.The Journal of allergy and clinical immunology · 2022Review
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
It is critical, both for the host and for the long-term benefit of the bacteria that colonize the gut, that bacterial overgrowth with subsequent bacterial translocation, which may lead to sepsis and death of the host, be avoided. Secretory IgA (sIgA) is known to be a key factor in this process, agglutinating bacteria and preventing their translocation in a process termed 'immune exclusion'. To determine whether human sIgA might facilitate the growth of normal enteric bacteria under some conditions, the growth of human enteric bacteria on cultured, fixed human epithelial cells was evaluated in the presence of sIgA or various other proteins. Human sIgA was found to facilitate biofilm formation by normal human gut flora and by Escherichia coli on cultured human epithelial cell surfaces under conditions in which non-adherent bacteria were repeatedly washed away. In addition, the presence of sIgA resulted in a 64% increase in adherence of E. coli to live cultured epithelial cells over a 45-min period. Mucin, another defence factor thought to play a key role in immune exclusion, was found to facilitate biofilm formation by E. coli. Our findings suggest that sIgA may contribute to biofilm formation in the gut.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.