ArticleImmunology2003
Genomic structure around joining segments and constant regions of swine T-cell receptor alpha/delta (TRA/TRD) locus.
Article in Immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- A specific promoter-type in ribonuclease L gene is associated with phagocytic activity in pigs.The Journal of veterinary medical science · 2021Article
- CD3εFrontiers in immunology · 2020Article
- Mucosal-Associated Invariant T Cells Expressing the TRAV1-TRAJ33 Chain Are Present in Pigs.Frontiers in immunology · 2019Article
- Structural and functional annotation of the porcine immunome.BMC genomics · 2013Article
- Article
- Comparative analysis of the chicken TCRα/δ locus.Immunogenetics · 2012Article
- Signal joint T-cell receptor excision circle assay in miniature swine.Transplantation · 2011Article
- The isolator piglet: a model for studying the development of adaptive immunity.Immunologic research · 2007Review
- TRAV gene usage in pig T-cell receptor alpha cDNA.Immunogenetics · 2005Article
- Comparison of the expressed porcine Vbeta and Jbeta repertoire of thymocytes and peripheral T cells.Immunology · 2005Article
- PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries.Nucleic acids research · 2004Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A complete genomic region of 131.2 kb including the swine T-cell receptor alpha/delta constant region (TRAC/TRDC) and joining segments (TRAJ/TRDJ) was sequenced. The structure of this region was strikingly conserved in comparison to that of human or mouse. All of the 61 TRAJ segments detected in the human genomic sequence were detected in the swine sequence and the sequence of the protein binding site of T early alpha, the sequence of the alpha enhancer element and the conserved sequence block between TRAJ3 and TRAJ4 are highly conserved. Insertion of the repetitive sequences that interspersed after the differentiation of the species in mammals such as short interspersed nucleotide elements is markedly suppressed in comparison to other genomic regions, while the composition of the mammalian-wide interspersed sequences is relatively conserved in human and swine. This observation indicates the existence of a highly selective pressure to conserve this genomic region around TRAJ throughout the evolution of mammals.
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Registered trials
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