Trial reportDigestive diseases and sciences2003
Guar attenuates fall in postprandial blood pressure and slows gastric emptying of oral glucose in type 2 diabetes.
Trial report in Digestive diseases and sciences, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02324010 (Effects of Sitagliptin on Postprandial Glycaemia, Incretin Hormones and Blood Pressure in Type 2 Diabetes - Relationship to Gastric Emptying), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Sitagliptin on Postprandial Glycaemia, Incretin Hormones and Blood Pressure in Type 2 Diabetes - Relationship to Gastric Emptying
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Acute Effects of Nutritive and Non-Nutritive Sweeteners on Postprandial Blood Pressure.Nutrients · 2019Pooled it
- A randomized, crossover study of the acute effects of acarbose and gastric distension, alone and combined, on postprandial blood pressure in healthy older adults.BMC geriatrics · 2019Trial
- Effect of a low dose whey/guar preload on glycemic control in people with type 2 diabetes--a randomised controlled trial.Nutrition journal · 2014Trial
- Effect of alginate on satiation, appetite, gastric function, and selected gut satiety hormones in overweight and obesity.Obesity (Silver Spring, Md.) · 2010Trial
- Effects of intraduodenal glucose concentration on blood pressure and heart rate in healthy older subjects.Digestive diseases and sciences · 2006Trial
- Postprandial Glycemic and Satiety Responses to Cooked Quinoa: A Randomized Crossover Preliminary Study.Foods (Basel, Switzerland) · 2026Article
- Effects of quinoa on cardiovascular disease and diabetes: a review.Frontiers in nutrition · 2024Review
- The role of selected nutraceuticals in management of prediabetes and diabetes: An updated review of the literature.Phytotherapy research : PTR · 2022Review
- Comparative effects of low-carbohydrate, full-strength and low-alcohol beer on gastric emptying, alcohol absorption, glycaemia and insulinaemia in health.British journal of clinical pharmacology · 2022Article
- Review
- Gastrointestinal Mechanisms Underlying the Cardiovascular Effect of Metformin.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Article
- Insights on Obesity in Children and Adults: Individualizing Management.Trends in endocrinology and metabolism: TEM · 2019Review
- Simulation of gastric bypass effects on glucose metabolism and non-alcoholic fatty liver disease with the Sleeveballoon device.EBioMedicine · 2019Article
- Current pharmacological management of hypotensive syndromes in the elderly.Drugs & aging · 2015Review
- Relationships between gastric emptying, postprandial glycemia, and incretin hormones.Diabetes care · 2013Review
- Review
- The effect of intraduodenal glucose on muscle sympathetic nerve activity in healthy young and older subjects.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2008Article
- Effects of diet supplementation with olive oil and guar upon fructose-induced insulin resistance in normal rats.Endocrine · 2007Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postprandial hypotension occurs frequently in diabetes; the fall in blood pressure is greatest after ingestion of carbohydrate, particularly glucose and, in type 2 diabetes, is related to the rate of gastric emptying. The aim of this study was to determine whether slowing of gastric emptying by guar gum reduces the fall in blood pressure after oral glucose in patients with type 2 diabetes. Eleven type 2 patients managed by diet alone, age 61.9 +/- 1.3 years, had measurements of gastric emptying, blood pressure, blood glucose, and serum insulin on two occasions after ingestion of 300 ml water containing 50 g glucose, with or without 9 g guar gum. The magnitude of the fall in blood pressure was less (P < 0.05) and gastric emptying slower (P < 0.05) after guar. Blood glucose (P < 0.05) and serum insulin (P < 0.01) concentrations were lower after guar. The magnitude of the fall in systolic blood pressure was related to gastric emptying of glucose at 30 min on the control day (r = 0.67, P < 0.05). We conclude that guar gum attenuates the fall in blood pressure after oral glucose in patients with type 2 diabetes mellitus, presumably by slowing glucose absorption.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.