ArticleGenome research2003
Integrated mapping, chromosomal sequencing and sequence analysis of Cryptosporidium parvum.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 63 citations in OpenAlex.
- Gene regulation inCurrent research in parasitology & vector-borne diseases · 2025Article
- Paving the Way: Contributions of Big Data to Apicomplexan and Kinetoplastid Research.Frontiers in cellular and infection microbiology · 2022Review
- Long-read assembly and comparative evidence-based reanalysis ofGenome research · 2022Article
- Comparative analyses and structural insights of new class glutathione transferases in Cryptosporidium species.Scientific reports · 2020Article
- Article
- Comparative genomics: how has it advanced our knowledge of cryptosporidiosis epidemiology?Parasitology research · 2019Review
- Divergent Copies of aMicroorganisms · 2019Article
- ApiAP2 Transcription Factors in Apicomplexan Parasites.Pathogens (Basel, Switzerland) · 2019Review
- An ApiAP2 member regulates expression of clonally variant genes of the human malaria parasite Plasmodium falciparum.Scientific reports · 2017Article
- Genome-wide upstream motif analysis of Cryptosporidium parvum genes clustered by expression profile.BMC genomics · 2013Article
- Library of Apicomplexan Metabolic Pathways: a manually curated database for metabolic pathways of apicomplexan parasites.Nucleic acids research · 2013Article
- Article
- Article
- Identification of intracellular and plasma membrane calcium channel homologues in pathogenic parasites.PloS one · 2011Article
- Structure and RNA recognition by the snRNA and snoRNA transport factor PHAX.RNA (New York, N.Y.) · 2010Article
- Conservation and divergence of known apicomplexan transcriptional regulons.BMC genomics · 2010Article
- Role of CpSUB1, a subtilisin-like protease, in Cryptosporidium parvum infection in vitro.Eukaryotic cell · 2009Article
- New eukaryotic systematics: a phylogenetic perspective of developmental gene expression in the Apicomplexa.International journal for parasitology · 2009Review
- Identification and functional characterization of cis-regulatory elements in the apicomplexan parasite Toxoplasma gondii.Genome biology · 2009Article
- Sequencing and analysis of chromosome 1 of Eimeria tenella reveals a unique segmental organization.Genome research · 2007Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The apicomplexan Cryptosporidium parvum is one of the most prevalent protozoan parasites of humans. We report the physical mapping of the genome of the Iowa isolate, sequencing and analysis of chromosome 6, and approximately 0.9 Mbp of sequence sampled from the remainder of the genome. To construct a robust physical map, we devised a novel and general strategy, enabling accurate placement of clones regardless of clone artefacts. Analysis reveals a compact genome, unusually rich in membrane proteins. As in Plasmodium falciparum, the mean size of the predicted proteins is larger than that in other sequenced eukaryotes. We find several predicted proteins of interest as potential therapeutic targets, including one exhibiting similarity to the chloroquine resistance protein of Plasmodium. Coding sequence analysis argues against the conventional phylogenetic position of Cryptosporidium and supports an earlier suggestion that this genus arose from an early branching within the Apicomplexa. In agreement with this, we find no significant synteny and surprisingly little protein similarity with Plasmodium. Finally, we find two unusual and abundant repeats throughout the genome. Among sequenced genomes, one motif is abundant only in C. parvum, whereas the other is shared with (but has previously gone unnoticed in) all known genomes of the Coccidia and Haemosporida. These motifs appear to be unique in their structure, distribution and sequences.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.