ArticleGenome research2003
The origin of human chromosome 1 and its homologs in placental mammals.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 80 citations in OpenAlex.
- Comparative Genomics Reveals the Ancestral Recombination Landscape of Placental Mammals.bioRxiv : the preprint server for biology · 2026Article
- Analysis of pregnancy and neonatal outcomes in 100 pregnant women with Rh-negative blood type.BMC pregnancy and childbirth · 2024Article
- A genomic timescale for placental mammal evolution.Science (New York, N.Y.) · 2023Article
- Rhesus Negativity Prevalence and Neonatal Outcomes among Pregnant Women Delivered at Bule Hora University Teaching Hospital, West Guji Zone, South Ethiopia.Clinical medicine insights. Pediatrics · 2023Article
- A rigorousFrontiers in molecular neuroscience · 2022Article
- Role of Gene Length in Control of Human Gene Expression: Chromosome-Specific and Tissue-Specific Effects.International journal of genomics · 2021Article
- New de novo assembly of the Atlantic bottlenose dolphin (Tursiops truncatus) improves genome completeness and provides haplotype phasing.GigaScience · 2019Article
- Chromosomal evolution among leaf-nosed nectarivorous bats--evidence from cross-species chromosome painting (Phyllostomidae, Chiroptera).BMC evolutionary biology · 2013Article
- Chromosome painting in three-toed sloths: a cytogenetic signature and ancestral karyotype for Xenarthra.BMC evolutionary biology · 2012Article
- Review
- A robust linkage map of the porcine autosomes based on gene-associated SNPs.BMC genomics · 2009Article
- A methodological framework for the reconstruction of contiguous regions of ancestral genomes and its application to mammalian genomes.PLoS computational biology · 2008Article
- Refinement of macaque synteny arrangement with respect to the official rheMac2 macaque sequence assembly.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Article
- Chromosomal instability in Afrotheria: fragile sites, evolutionary breakpoints and phylogenetic inference from genome sequence assemblies.BMC evolutionary biology · 2007Article
- Characterization of the human lineage-specific pericentric inversion that distinguishes human chromosome 1 from the homologous chromosomes of the great apes.Human genetics · 2006Article
- The ancestral eutherian karyotype is present in Xenarthra.PLoS genetics · 2006Article
- Are molecular cytogenetics and bioinformatics suggesting diverging models of ancestral mammalian genomes?Genome research · 2006Article
- Comparative genome maps of the pangolin, hedgehog, sloth, anteater and human revealed by cross-species chromosome painting: further insight into the ancestral karyotype and genome evolution of eutherian mammals.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2006Article
- Reconstruction of the ancestral ferungulate karyotype by electronic chromosome painting (E-painting).Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2006Article
- High-resolution comparative chromosome painting in the Arizona collared peccary (Pecari tajacu, Tayassuidae): a comparison with the karyotype of pig and sheep.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2006Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Developing ordered gene maps from multiple mammalian species coupled with chromosome-painting data provide a powerful resource for resolving the evolutionary history of chromosomes and whole genomes. In this work, we recapitulate the evolutionary history of human chromosome 1 and its homologs in placental mammals, putatively the largest physical unit in the ancestral placental genome. Precise definition of translocation exchange breakpoints in human, carnivore, cetartiodactyl, and rodent-ordered gene maps demonstrate that chromosome breakpoints, previously considered as equivalent, actually represent distinct chromosome positions and exchange events. Multidirectional chromosome painting, using probes from homologs to chromosome 1 in seven mammal species from six orders of placental mammals, confirm the gene-mapping results and indicate that the multiple human chromosome 1 homologs in these species are derived from independent fissions of a single ancestral chromosome. Chromosome painting using human chromosome 1 probes identifies a single human chromosome 1 homolog in phylogenetically distant taxa, the two-toed sloth, cetaceans, and higher primates. The diverse phylogenetic occurrence of a single Hsa1 synteny among the major clades of placental mammals suggests that human chromosome 1 represents an intact ancestral chromosome, which was variously fissioned in the majority of placental species. We find that the number of human chromosome 1 fissions in a specific lineage reflects its general rate of genomic evolution. Further, historic chromosome exchange appears to have been disproportionately clustered in two breakpoint hotspots on the long arm.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.