ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Calcium dependence of retrograde inhibition by endocannabinoids at synapses onto Purkinje cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 114 citations in OpenAlex.
- α2δ-2 is required for depolarization-induced suppression of excitation in Purkinje cells.The Journal of physiology · 2022Article
- Review
- Autonomous Purkinje cell activation instructs bidirectional motor learning through evoked dendritic calcium signaling.Nature communications · 2021Article
- Cannabinoid type 2 receptors inhibit GABAA receptor-mediated currents in cerebellar Purkinje cells of juvenile mice.PloS one · 2020Article
- Long-term depression of presynaptic cannabinoid receptor function at parallel fibre synapses.The Journal of physiology · 2019Article
- Complex Spike Wars: a New Hope.Cerebellum (London, England) · 2018Review
- Cell-Autonomous Excitation of Midbrain Dopamine Neurons by Endocannabinoid-Dependent Lipid Signaling.Neuron · 2017Article
- Climbing Fibers Control Purkinje Cell Representations of Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Article
- Review: CaThe open neurology journal · 2016Article
- Location matters: somatic and dendritic SK channels answer to distinct calcium signals.Journal of neurophysiology · 2015Article
- Fast calcium sensor proteins for monitoring neural activity.Neurophotonics · 2014Article
- Fmr1 deletion enhances and ultimately desensitizes CB(1) signaling in autaptic hippocampal neurons.Neurobiology of disease · 2013Article
- Beyond "all-or-nothing" climbing fibers: graded representation of teaching signals in Purkinje cells.Frontiers in neural circuits · 2013Review
- Fast GCaMPs for improved tracking of neuronal activity.Nature communications · 2013Article
- Article
- Cellular signal mechanisms of reward-related plasticity in the hippocampus.Neural plasticity · 2012Review
- Sustained firing of cartwheel cells in the dorsal cochlear nucleus evokes endocannabinoid release and retrograde suppression of parallel fiber synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Purine receptor-mediated endocannabinoid production and retrograde synaptic signalling in the cerebellar cortex.British journal of pharmacology · 2011Article
- Presynaptic CB1 receptors regulate synaptic plasticity at cerebellar parallel fiber synapses.Journal of neurophysiology · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Many types of neurons release endocannabinoids from their dendrites in response to elevation of intracellular calcium levels. Endocannabinoids then activate presynaptic cannabinoid receptors, thereby inhibiting neurotransmitter release for tens of seconds. A crucial step in understanding the physiological role of this retrograde signaling is to determine its sensitivity to elevations of postsynaptic calcium. Here we determine and compare the calcium dependence of endocannabinoid-mediated retrograde inhibition at three types of synapses onto cerebellar Purkinje cells. Previous studies have shown that Purkinje cell depolarization results in endocannabinoid-mediated retrograde inhibition of synapses received from climbing fibers, granule cell parallel fibers, and inhibitory interneurons. Using several calcium indicators with a range of affinities, we performed a series of in situ and in vitro calibrations to quantify calcium levels in Purkinje cells. We found that postsynaptic calcium levels of approximately 15 microM are required for half-maximal retrograde inhibition at all of these synapses. In contrast, previous studies had suggested that endocannabinoid release could occur with slight elevations of calcium above resting levels, which implies that inhibition should be widespread and continuously modulated by subtle changes in intracellular calcium levels. However, our results indicate that such small changes in intracellular calcium are not sufficient to evoke endocannabinoid release. Instead, because of its high requirement for calcium, retrograde inhibition mediated by calcium-dependent endocannabinoid release from Purkinje cells will occur under more restricted conditions and with greater spatial localization than previously appreciated.
Indexed as
Identifiers
12867523PMC6740543W1951096396What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.