ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Priming of excitatory synapses by alpha1 adrenoceptor-mediated inhibition of group III metabotropic glutamate receptors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- The Neuromodulatory Role of the Noradrenergic and Cholinergic Systems and Their Interplay in Cognitive Functions: A Focused Review.Brain sciences · 2022Review
- Group III metabotropic glutamate receptors regulate hypothalamic presympathetic neurons through opposing presynaptic and postsynaptic actions in hypertension.Neuropharmacology · 2020Article
- αFrontiers in pharmacology · 2020Review
- Activation of lateral hypothalamic group III metabotropic glutamate receptors suppresses cocaine-seeking following abstinence and normalizes drug-associated increases in excitatory drive to orexin/hypocretin cells.Neuropharmacology · 2019Article
- Presynaptic mGluRs Control the Duration of Endocannabinoid-Mediated DSI.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Excitatory drive onto dopaminergic neurons in the rostral linear nucleus is enhanced by norepinephrine in an α1 adrenergic receptor-dependent manner.Neuropharmacology · 2014Article
- Norepinephrine drives persistent activity in prefrontal cortex via synergistic α1 and α2 adrenoceptors.PloS one · 2013Article
- Activation of alpha1-adrenoceptors enhances glutamate release onto ventral tegmental area dopamine cells.Neuroscience · 2012Article
- Short-term plasticity impacts information transfer at glutamate synapses onto parvocellular neuroendocrine cells in the paraventricular nucleus of the hypothalamus.The Journal of physiology · 2011Article
- mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- Cardiac and neuroprotection regulated by α(1)-adrenergic receptor subtypes.Journal of receptor and signal transduction research · 2011Review
- Opposing actions of endothelin-1 on glutamatergic transmission onto vasopressin and oxytocin neurons in the supraoptic nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Modulation of glutamatergic synaptic transmission in the bed nucleus of the stria terminalis.Progress in neuro-psychopharmacology & biological psychiatry · 2009Review
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- Retrograde opioid signaling regulates glutamatergic transmission in the hypothalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Noradrenaline triggers muscle tone by amplifying glutamate-driven excitation of somatic motoneurones in anaesthetized rats.The Journal of physiology · 2008Article
- Alpha1-adrenergic receptor-induced heterosynaptic long-term depression in the bed nucleus of the stria terminalis is disrupted in mouse models of affective disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2008Article
- Can homeostatic circuits learn and remember?The Journal of physiology · 2006Review
- Noradrenaline triggers multivesicular release at glutamatergic synapses in the hypothalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adaptive responses mediated by the hypothalamus require sustained activation until homeostasis is achieved. Increases in excitatory drive to the magnocellular neuroendocrine cells that mediate these responses, however, result in the activation of a presynaptic metabotropic glutamate receptor (mGluR) that curtails synaptic excitability. Recent evidence that group III mGluRs can be inhibited by protein kinase C prompted us to test the hypothesis that activation of PKC by noradrenaline (NA) inhibits group III mGluRs and increases excitatory synaptic input to these cells. To examine the effects of NA on miniature EPSCs (mEPSCs), we obtained whole-cell recordings from magnocellular vasopressin and oxytocin neurons in the paraventricular nucleus of the hypothalamus. All of the neurons tested in the current study displayed an alpha1 adrenoceptor-mediated increase in mEPSC frequency in response to NA (1-200 microm). The excitatory effects of NA were mimicked by the phorbol ester PMA and blocked by the PKC inhibitor calphostin C. The activation of PKC inhibits the efficacy of group III mGluRs, resulting in an increase in mEPSC frequency in response to a subsequent exposure to NA. By removing feedback inhibition, this mechanism effectively primes the synapses such that subsequent activation is more efficacious. The novel form of synaptic rescaling afforded by this cross-talk between distinct metabotropic receptors provides a means by which ascending catecholamine inputs can facilitate the control of homeostasis by hypothalamic networks.
Indexed as
Identifiers
12867506PMC6740556W1859305961What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.