ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Actin filament-stabilizing protein tropomyosin regulates the size of dendritic fields.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Form and function of actin impacts actin health and aging.iScience · 2026Article
- Patronin facilitates neurite remodeling via epithelial-to-neuronal signaling.Cell communication and signaling : CCS · 2026Article
- Form and function of actin impacts actin health and aging.bioRxiv : the preprint server for biology · 2025Article
- Robust identification of interactions between heat-stress responsive genes in the chicken brain using Bayesian networks and augmented expression data.Scientific reports · 2024Article
- Integrative Genomics Reveals the Genetics and Evolution of the Honey Bee's Social Immune System.Genome biology and evolution · 2019Article
- Long Oskar Controls Mitochondrial Inheritance in Drosophila melanogaster.Developmental cell · 2016Article
- Building Blocks of Functioning Brain: Cytoskeletal Dynamics in Neuronal Development.International review of cell and molecular biology · 2016Review
- A novel tropomyosin isoform functions at the mitotic spindle and Golgi in Drosophila.Molecular biology of the cell · 2015Article
- International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.Pharmacological reviews · 2015Review
- Epidermal growth factor, latrophilin, and seven transmembrane domain-containing protein 1 marker, a novel angiogenesis marker.OncoTargets and therapy · 2015Review
- Cell-intrinsic drivers of dendrite morphogenesis.Development (Cambridge, England) · 2013Review
- Post-transcriptional regulation of myotube elongation and myogenesis by Hoi Polloi.Development (Cambridge, England) · 2013Article
- Increased expression of actin filament-stabilizing protein tropomyosin after rat traumatic brain injury.Journal of molecular histology · 2013Article
- Immunohistological labeling of microtubules in sensory neuron dendrites, tracheae, and muscles in the Drosophila larva body wall.Journal of visualized experiments : JoVE · 2011Article
- Internal and external paralogy in the evolution of tropomyosin genes in metazoans.Molecular biology and evolution · 2010Article
- Branching out: mechanisms of dendritic arborization.Nature reviews. Neuroscience · 2010Review
- Molecules and mechanisms of dendrite development in Drosophila.Development (Cambridge, England) · 2009Review
- Specific features of neuronal size and shape are regulated by tropomyosin isoforms.Molecular biology of the cell · 2005Article
- Gamma tropomyosin gene products are required for embryonic development.Molecular and cellular biology · 2004Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic arbors of different neuronal subtypes cover distinct spatial territories, known as dendritic fields, to receive specific inputs in a nervous system. How the size of dendritic fields is determined by cell-intrinsic factors during development remains primarily unknown. To address this issue, we used the Drosophila embryonic peripheral nervous system. In each hemisegment, six dorsal cluster dendritic arborization (DA) neurons elaborate stereotypic dendritic branching patterns underneath the epidermis. Here we report the identification of loss-of-function mutations in the tropomyosin II gene (TmII) that result in expanded dendritic fields of DA neurons. Mosaic analysis with a repressible cell marker demonstrated that TmII functions in a cell-autonomous manner to control the formation of dendritic fields. Furthermore, we show that TmII genetically interacted with flamingo, a gene encoding a membrane receptor-like molecule that affects dendritic growth. TmII encodes multiple isoforms of a protein that stabilizes actin filaments. Our findings suggest that tropomyosin helps control the size of dendritic fields by regulating actin cytoskeletal dynamics.
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12867499PMC6740560What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.