ArticleJournal of bacteriology2003
Essential nature of the mreC determinant of Bacillus subtilis.
Article in Journal of bacteriology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- A broadly conserved gram-positive lipoprotein regulates cell elongation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Conformational regulation of two essential activators of bacterial cell elongation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- MreC-MreD structure reveals a multifaceted interface that controls MreC conformation.bioRxiv : the preprint server for biology · 2024Article
- CroR Regulates Expression ofmBio · 2022Article
- Subgingival microbiome in periodontitis and type 2 diabetes mellitus: an exploratory study using metagenomic sequencing.Journal of periodontal & implant science · 2022Article
- A High-Content Microscopy Screening Identifies New Genes Involved in Cell Width Control in Bacillus subtilis.mSystems · 2021Article
- Article
- Coarse-grained simulations of bacterial cell wall growth reveal that local coordination alone can be sufficient to maintain rod shape.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Reconstruction of mreB expression in Staphylococcus aureus via a collection of new integrative plasmids.Applied and environmental microbiology · 2014Article
- Motion of variable-length MreB filaments at the bacterial cell membrane influences cell morphology.Molecular biology of the cell · 2013Article
- The small protein MbiA interacts with MreB and modulates cell shape in Caulobacter crescentus.Molecular microbiology · 2012Article
- The requirement for pneumococcal MreC and MreD is relieved by inactivation of the gene encoding PBP1a.Journal of bacteriology · 2011Article
- Conformational dynamics of actin: effectors and implications for biological function.Cytoskeleton (Hoboken, N.J.) · 2010Review
- RodZ, a component of the bacterial core morphogenic apparatus.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Functional definition and global regulation of Zur, a zinc uptake regulator in a Streptococcus suis serotype 2 strain causing streptococcal toxic shock syndrome.Journal of bacteriology · 2008Article
- The bacterial actin-like cytoskeleton.Microbiology and molecular biology reviews : MMBR · 2006Review
- The cell-shape protein MreC interacts with extracytoplasmic proteins including cell wall assembly complexes in Caulobacter crescentus.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Two independent spiral structures control cell shape in Caulobacter.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Bacterial cell wall synthesis: new insights from localization studies.Microbiology and molecular biology reviews : MMBR · 2005Review
- Gene silencing and overexpression of porcine peptidoglycan recognition protein long isoforms: involvement in beta-defensin-1 expression.Infection and immunity · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The mre genes of Escherichia coli and Bacillus subtilis are cell shape determination genes. Mutants affected in mre function are spheres instead of the normal rods. Although the mre determinants are not required for viability in E. coli, the mreB determinant is an essential gene in B. subtilis. Conflicting results have been reported as to whether the two membrane-associated proteins MreC and MreD are essential proteins. Furthermore, although the MreB protein has been studied in some detail, the roles of the MreC and MreD proteins in cell shape determination are unknown. We constructed a strain of B. subtilis in which expression of the mreC determinant is dependent upon the addition of isopropyl-beta-D-thiogalactopyranoside to the culture medium. Utilizing this conditional strain, it was shown that mreC is an essential gene in B. subtilis. Furthermore, it was shown that cells lacking sufficient quantities of MreC undergo morphological changes, namely, swelling and twisting of the cells, which is followed by cell lysis. Electron microscopy was utilized to demonstrate that a polymeric material accumulated at one side of the division septum of the cells and that the presence of this material correlated with the bending of the cell. The best explanation for the results is that the MreC protein is involved in the control of septal versus long-axis peptidoglycan synthesis, that cells lacking MreC perform aberrant septal peptidoglycan synthesis, and that lysis results from a deficiency in long-axis peptidoglycan synthesis.
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