ArticleJournal of bacteriology2003
The core dimerization domains of histidine kinases contain recognition specificity for the cognate response regulator.
Article in Journal of bacteriology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 58 citations in OpenAlex.
- Widespread potential for phototrophy and convergent reduction of lifecycle complexity in the dimorphic order Caulobacterales.Nature communications · 2025Article
- Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ.eLife · 2021Article
- Regulation of Bacterial Cell Cycle Progression by Redundant Phosphatases.Journal of bacteriology · 2020Article
- Cell fate regulation governed by a repurposed bacterial histidine kinase.PLoS biology · 2014Article
- A signaling pathway involving the diguanylate cyclase CelR and the response regulator DivK controls cellulose synthesis in Agrobacterium tumefaciens.Journal of bacteriology · 2014Article
- Fast and accurate multivariate Gaussian modeling of protein families: predicting residue contacts and protein-interaction partners.PloS one · 2014Article
- The DivJ, CbrA and PleC system controls DivK phosphorylation and symbiosis in Sinorhizobium meliloti.Molecular microbiology · 2013Article
- Potential role of a bistable histidine kinase switch in the asymmetric division cycle of Caulobacter crescentus.PLoS computational biology · 2013Article
- Polarity and cell fate asymmetry in Caulobacter crescentus.Current opinion in microbiology · 2012Review
- Protein-protein interactions between histidine kinases and response regulators of Mycobacterium tuberculosis H37Rv.Journal of microbiology (Seoul, Korea) · 2012Article
- Dynamics and activation in response regulators: the β4-α4 loop.Biomolecular concepts · 2012Article
- Interplay between the localization and kinetics of phosphorylation in flagellar pole development of the bacterium Caulobacter crescentus.PLoS computational biology · 2012Article
- Article
- Molecular signaling mechanisms of the periopathogen, Treponema denticola.Journal of dental research · 2011Review
- Dissecting the specificity of protein-protein interaction in bacterial two-component signaling: orphans and crosstalks.PloS one · 2011Article
- A dynamic complex of signaling proteins uses polar localization to regulate cell-fate asymmetry in Caulobacter crescentus.Developmental cell · 2011Article
- The Hpk2-Rrp2 two-component regulatory system of Treponema denticola: a potential regulator of environmental and adaptive responses.Molecular oral microbiology · 2010Article
- The diversity and evolution of cell cycle regulation in alpha-proteobacteria: a comparative genomic analysis.BMC systems biology · 2010Article
- Getting in the loop: regulation of development in Caulobacter crescentus.Microbiology and molecular biology reviews : MMBR · 2010Review
- Complex regulatory pathways coordinate cell-cycle progression and development in Caulobacter crescentus.Advances in microbial physiology · 2009Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Histidine kinases DivJ and PleC initiate signal transduction pathways that regulate an early cell division cycle step and the gain of motility later in the Caulobacter crescentus cell cycle, respectively. The essential single-domain response regulator DivK functions downstream of these kinases to catalyze phosphotransfer from DivJ and PleC. We have used a yeast two-hybrid screen to investigate the molecular basis of DivJ and PleC interaction with DivK and to identify other His-Asp signal transduction proteins that interact with DivK. The only His-Asp proteins identified in the two-hybrid screen were five members of the histidine kinase superfamily. The finding that most of the kinase clones isolated correspond to either DivJ or PleC supports the previous conclusion that DivJ and PleC are cognate DivK kinases. A 66-amino-acid sequence common to all cloned DivJ and PleC fragments contains the conserved helix 1, helix 2 sequence that forms a four-helix bundle in histidine kinases required for dimerization, autophosphorylation and phosphotransfer. We present results that indicate that the four-helix bundle subdomain is not only necessary for binding of the response regulator but also sufficient for in vivo recognition specificity between DivK and its cognate histidine kinases. The other three kinases identified in this study correspond to DivL, an essential tyrosine kinase belonging to the same kinase subfamily as DivJ and PleC, and the two previously uncharacterized, soluble histidine kinases CckN and CckO. We discuss the significance of these results as they relate to kinase response regulator recognition specificity and the fidelity of phosphotransfer in signal transduction pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.