ArticleJournal of bacteriology2003
NhaR and RcsB independently regulate the osmCp1 promoter of Escherichia coli at overlapping regulatory sites.
Article in Journal of bacteriology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Distribution and evolution of the LysR-type transcriptional regulators of the Salmonella genus.PloS one · 2026Article
- A Holling Functional Response Model for Mapping QTLs Governing Interspecific Interactions.Frontiers in genetics · 2021Article
- Article
- Global Regulator of Virulence A (GrvA) Coordinates Expression of Discrete Pathogenic Mechanisms in Enterohemorrhagic Escherichia coli through Interactions with GadW-GadE.Journal of bacteriology · 2016Article
- Interaction of the RcsB Response Regulator with Auxiliary Transcription Regulators in Escherichia coli.The Journal of biological chemistry · 2016Article
- Functional characterization of osmotically inducible protein C (MG_427) from Mycoplasma genitalium.Journal of bacteriology · 2014Article
- Transcriptional regulation by BglJ-RcsB, a pleiotropic heteromeric activator in Escherichia coli.Nucleic acids research · 2014Article
- Article
- Proteomic analysis of the quorum-sensing regulon in Pantoea stewartii and identification of direct targets of EsaR.Applied and environmental microbiology · 2013Article
- The response regulator RcsB activates expression of Mat fimbriae in meningitic Escherichia coli.Journal of bacteriology · 2012Article
- Nε-lysine acetylation of a bacterial transcription factor inhibits Its DNA-binding activity.PloS one · 2010Article
- BglJ-RcsB heterodimers relieve repression of the Escherichia coli bgl operon by H-NS.Journal of bacteriology · 2010Article
- Structural and functional characterization of an organic hydroperoxide resistance protein from Mycoplasma gallisepticum.Journal of bacteriology · 2008Article
- The cation-responsive protein NhaR of Escherichia coli activates pgaABCD transcription, required for production of the biofilm adhesin poly-beta-1,6-N-acetyl-D-glucosamine.Journal of bacteriology · 2006Article
- A complex transcription network controls the early stages of biofilm development by Escherichia coli.Journal of bacteriology · 2006Review
- Osmotic regulation of the Escherichia coli bdm (biofilm-dependent modulation) gene by the RcsCDB His-Asp phosphorelay.Journal of bacteriology · 2005Article
- Multistress regulation in Escherichia coli: expression of osmB involves two independent promoters responding either to sigmaS or to the RcsCDB His-Asp phosphorelay.Journal of bacteriology · 2005Article
- The LysR-type transcriptional regulator VirR is required for expression of the virulence gene vapA of Rhodococcus equi ATCC 33701.Journal of bacteriology · 2004Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcription of the Escherichia coli osmC gene is induced by several stress conditions. osmC is expressed from two overlapping promoters, osmCp1 and osmCp2. The proximal promoter, osmCp2, is transcribed at the entry into the stationary phase by the sigma(s) sigma factor. The distal promoter, osmCp1, is activated by NhaR and RcsB. NhaR is a positive regulator of the LysR family and is known to be an activator of the nhaA gene encoding an Na(+)/H(+) antiporter. RcsB is the response regulator of the RcsCDB His-Asp phosphorelay signal transduction system. Genetic data indicated that activation of osmCp1 by both NhaR and RcsB requires the same short sequences upstream of the -35 region of the promoter. Accordingly, DNase I footprint analysis indicated that both activators protect an overlapping region close to the -35 box of the promoter and suggested that the regulatory effect is direct. Despite the overlap of the binding sites, each activator acts independent of the other and is specific for a particular stress. NhaR can stimulate osmCp1 in response to an osmotic signal even in the absence of RcsB. RcsB is responsible for the induction of osmCp1 by alteration of the cell envelope, even in the absence of NhaR. osmCp1 as an example of multiple-stress-responsive promoter is discussed in light of a comparison of the NhaR and RcsB target regions in the Enterobacteriaceae.
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