ArticleMolecular medicine (Cambridge, Mass.)
Identification of early secretory antigen target-6 epitopes for the immunodiagnosis of active tuberculosis.
Article in Molecular medicine (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 53 citations in OpenAlex.
- Trial
- Accuracy of immunodiagnostic tests for active tuberculosis using single and combined results: a multicenter TBNET-Study.PloS one · 2008Trial
- Current Melioidosis Diagnostic Landscape and Missed Opportunities in Biomarker Development.Diagnostics (Basel, Switzerland) · 2026Review
- A vaccine targeting lung resident-memory CD4NPJ vaccines · 2025Article
- Specific immune response toFrontiers in immunology · 2024Article
- Article
- Changes in cytokine responses to TB antigens ESAT-6, CFP-10 and TB 7.7 and inflammatory markers in peripheral blood during therapy.Scientific reports · 2018Article
- A T-cell diagnostic test for cystic echinococcosis based on Antigen B peptides.Parasite immunology · 2017Article
- TepiTool: A Pipeline for Computational Prediction of T Cell Epitope Candidates.Current protocols in immunology · 2016Article
- Dissecting mechanisms of immunodominance to the common tuberculosis antigens ESAT-6, CFP10, Rv2031c (hspX), Rv2654c (TB7.7), and Rv1038c (EsxJ).Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Diagnosing latent tuberculosis in high-risk individuals: rising to the challenge in high-burden areas.The Journal of infectious diseases · 2011Review
- IP-10 response to RD1 antigens might be a useful biomarker for monitoring tuberculosis therapy.BMC infectious diseases · 2011Article
- Is IP-10 an accurate marker for detecting M. tuberculosis-specific response in HIV-infected persons?PloS one · 2010Article
- Potential role for IL-2 ELISpot in differentiating recent and remote infection in tuberculosis contact tracing.PloS one · 2010Article
- Effects of antenatal and postnatal environments on CD4 T-cell responses to Mycobacterium bovis BCG in healthy infants in the Gambia.Clinical and vaccine immunology : CVI · 2008Article
- Response to region of difference 1 (RD1) epitopes in human immunodeficiency virus (HIV)-infected individuals enrolled with suspected active tuberculosis: a pilot study.Clinical and experimental immunology · 2007Article
- Isoniazid prophylaxis differently modulates T-cell responses to RD1-epitopes in contacts recently exposed to Mycobacterium tuberculosis: a pilot study.Respiratory research · 2007Article
- Selected RD1 peptides for active tuberculosis diagnosis: comparison of a gamma interferon whole-blood enzyme-linked immunosorbent assay and an enzyme-linked immunospot assay.Clinical and diagnostic laboratory immunology · 2005Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The early secretory antigenic target (ESAT)-6 purified protein and peptides from Mycobacterium tuberculosis were evaluated as antigens for the immunodiagnosis of tuberculosis (TB). Because the control of TB requires improved diagnostic procedures, efforts have increased to identify Mycobacterium tuberculosis-specific epitopes for the immunodiagnosis of active TB and to discriminate between active and latent states of infection. Two multiepitopic peptides from ESAT-6 protein were selected by computational analysis. Patients with active TB (7 HIV(+) and 20 HIV(-)) and control patients (17 HIV(+) and 28 HIV(-)) were enrolled. Enzyme-linked immunospot assay analysis for interferon-g expression by peripheral blood mononuclear cells was quantified after stimulation with selected ESAT-6 peptides, purified protein derivative, or the intact ESAT-6 protein. During active TB, 20 of 27 patients responded in vitro to ESAT-6 peptides and 23 of 27 patients to purified protein derivative. None of the controls without active TB, including individuals with latent TB infection, recognized ESAT-6 peptides. By contrast, latently infected individuals did respond in vitro to both intact ESAT-6 protein and purified protein derivative. Thus, high T-cell response frequencies to ESAT-6 peptides are present only during active TB and can be used to discriminate between active and latent forms of infection.
Indexed as
Identifiers
12865946PMC1430726W339337714What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.