ReviewCurrent gastroenterology reports2003
Acute acalculous cholecystitis.
Review in Current gastroenterology reports, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.
- Cholecystitis associated with Q fever: case report and systematic review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Pooled it
- Glucagon-Like Peptide 2 Inhibits Postprandial Gallbladder Emptying in Man: A Randomized, Double-Blinded, Crossover Study.Clinical and translational gastroenterology · 2020Trial
- The Causal Relationship Between Choline Metabolites and Acute Acalculous Cholecystitis: IdentifyingNutrients · 2024Article
- Review
- Review
- Rare or Overlooked Cases of Acute Acalculous Cholecystitis in Young Patients with Central Nervous System Lesion.Healthcare (Basel, Switzerland) · 2023Article
- Acute acalculous cholecystitis as a rare gastroenterological association of COVID-19: a case series and systematic review.Journal of clinical and translational research · 2023Review
- Acute acalculous cholecystitis in hospitalized patients in intensive care unit: study of 5 cases.Heliyon · 2022Article
- Rare But Fatal: Hemophagocytic Lymphohistiocytosis (HLH) With Acute Acalculous Cholecystitis.Cureus · 2022Article
- Outcomes Following Percutaneous Cholecystostomy Tube Placement for Acalculous Versus Calculous Cholecystitis.World journal of surgery · 2022Article
- Acalculous cholecystitis presentation in a young patient.Journal of family medicine and primary care · 2022Article
- Acute acalculous cholecystitis and cardiovascular disease, which came first? After two hundred years still the classic chicken and eggs debate: A review of literature.Annals of medicine and surgery (2012) · 2022Review
- Use of Gallbladder Width Measurement by Computed Tomography in the Diagnosis of Acute Cholecystitis.Diagnostics (Basel, Switzerland) · 2022Article
- Acute acalculous cholecystitis due to infectious causes.World journal of clinical cases · 2021Review
- Eosinophilic granulomatosis polyangiitis associated with acute acalculous cholecystitis.BMJ case reports · 2021Article
- Epstein-Barr Virus (EBV) acute acalculous cholecystitis in an immunocompromised adult patient: a case report and a literature review of a neglected clinical presentation.Journal of preventive medicine and hygiene · 2021Review
- Long-term outcomes of acute acalculous cholecystitis treated by non-surgical management.Medicine · 2020Article
- Systemic infection facilitates transmission of Pseudomonas aeruginosa in mice.Nature communications · 2020Article
- Acute Epstein-Barr infection presenting as cholecystitis with ascites.BMJ case reports · 2020Article
- A Rare Case of Systemic Adult Burkitt Lymphoma Presenting as Acute Acalculous Cholecystitis.ACG case reports journal · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute cholecystitis can develop without gallstones in critically ill or injured patients. However, the development of acute acalculous cholecystitis is not limited to surgical or injured patients, or even to the intensive care unit. Diabetes, malignant disease, abdominal vasculitis, congestive heart failure, cholesterol embolization, and shock or cardiac arrest have been associated with acute acalculous cholecystitis. Children may also be affected, especially after a viral illness. The pathogenesis of acute acalculous cholecystitis is a paradigm of complexity. Ischemia and reperfusion injury, or the effects of eicosanoid proinflammatory mediators, appear to be the central mechanisms, but bile stasis, opioid therapy, positive-pressure ventilation, and total parenteral nutrition have all been implicated. Ultrasound of the gallbladder is the most accurate diagnostic modality in the critically ill patient, with gallbladder wall thickness of 3.5 mm or greater and pericholecystic fluid being the two most reliable criteria. The historical treatment of choice for acute acalculous cholecystitis has been cholecystectomy, but percutaneous cholecystostomy is now the mainstay of therapy, controlling the disease in about 85% of patients. Rapid improvement can be expected when the procedure is performed properly. The mortality rates (historically about 30%) for percutaneous and open cholecystostomy appear to be similar, reflecting the severity of illness, but improved resuscitation and critical care may portend a decreased risk of death. Interval cholecystectomy is usually not indicated after acute acalculous cholecystitis in survivors; if the absence of gallstones is confirmed and the precipitating disorder has been controlled, the cholecystostomy tube can be pulled out after the patient has recovered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.