ArticleThe Journal of cell biology2003
Polyamines play a critical role in the control of the innate immune response in the mouse central nervous system.
Article in The Journal of cell biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 91 citations in OpenAlex.
- Polyamine metabolism in cancer: drivers of immune evasion, ferroptosis and therapy resistance.Expert reviews in molecular medicine · 2025Review
- Polyamine biosynthesis dysregulation in Alzheimer's disease and Down syndrome cellular models.bioRxiv : the preprint server for biology · 2025Article
- Arginine metabolism in myeloid cells in health and disease.Seminars in immunopathology · 2025Review
- The telencephalon is a neuronal substrate for systemic inflammatory responses in teleosts via polyamine metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Nanomaterials as drug delivery agents for overcoming the blood-brain barrier: A comprehensive review.ADMET & DMPK · 2024Review
- Development of an Untargeted Metabolomics Strategy to Study the Metabolic Rewiring of Dendritic Cells upon Lipopolysaccharide Activation.Metabolites · 2023Article
- Helping the helpers: polyamines help maintain helper T-cell lineage fidelity.Immunometabolism (Cobham, Surrey) · 2022Article
- Patients with hypothermic sepsis have a unique gene expression profile compared to patients with fever and sepsis.Journal of cellular and molecular medicine · 2022Article
- Polyamine Immunometabolism: Central Regulators of Inflammation, Cancer and Autoimmunity.Cells · 2022Review
- C1q deletion exacerbates stress-induced learned helplessness behavior and induces neuroinflammation in mice.Translational psychiatry · 2022Article
- The relationship between nutrition and the immune system.Frontiers in nutrition · 2022Review
- Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia.Journal of neuroinflammation · 2020Article
- Prevention of multiple system atrophy using human bone marrow-derived mesenchymal stem cells by reducing polyamine and cholesterol-induced neural damages.Stem cell research & therapy · 2020Article
- Sex-related differences in urinary immune-related metabolic profiling of alopecia areata patients.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- Effects of spermine on liver barrier function, amino acid transporters, immune status, and apoptosis in piglets.RSC advances · 2019Article
- Polyamines: Bio-Molecules with Diverse Functions in Plant and Human Health and Disease.Frontiers in chemistry · 2018Review
- Spermine reverses lipopolysaccharide-induced memory deficit in mice.Journal of neuroinflammation · 2015Article
- Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.Journal of neuroinflammation · 2014Review
- Natural polyamine inhibits mouse skin inflammation and macrophage activation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2013Article
- Autoimmune diseases and polyamines.Clinical reviews in allergy & immunology · 2012Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present work investigated whether polyamines play a role in the control of the innate immune response in the brain. The first evidence that these molecules may be involved in such a process was based on the robust increase in the expression of the first and rate-limiting enzyme of biosynthesis of polyamines during immune stimuli. Indeed, systemic lipopolysaccharide (LPS) administration increased ornithine decarboxylase (ODC) mRNA and protein within neurons and microglia across the mouse central nervous system (CNS). This treatment was also associated with a robust and transient transcriptional activation of genes encoding pro-inflammatory cytokines and toll-like receptor 2 (TLR2) in microglial cells. The endotoxin increased the cerebral activity of ODC, which was abolished by a suicide inhibitor of ODC. The decrease in putrescine levels largely prevented the ability of LPS to trigger tumor necrosis factor alpha and TLR2 gene transcription in the mouse brain. In contrast, expression of both transcripts was clearly exacerbated in response to intracerebral spermine infusion. Finally, inhibition of polyamine synthesis abolished neurodegeneration and increased the survival rate of mice exposed to a model of severe innate immune reaction in the CNS. Thus, polyamines have a major impact on the neuronal integrity and cerebral homeostasis during immune insults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.