ArticleThe Journal of experimental medicine2003
CD4+ T cell polarization in mice is modulated by strain-specific major histocompatibility complex-independent differences within dendritic cells.
Article in The Journal of experimental medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- The proteinase-activated receptor-2 mediates protective immunity in early experimental leishmaniasis.Emerging microbes & infections · 2026Article
- Lactobacilli Probiotics Modulate Antibacterial Response Gene Transcription of Dendritic Cells Challenged with LPS.Probiotics and antimicrobial proteins · 2024Article
- Article
- Myocardial-Treg Crosstalk: How to Tame a Wolf.Frontiers in immunology · 2022Review
- Interleukin-1 as Innate Mediator of T Cell Immunity.Frontiers in immunology · 2020Review
- TheFrontiers in microbiology · 2017Article
- Intrinsic Differences in Donor CD4 T Cell IL-2 Production Influence Severity of Parent-into-F1 Murine Lupus by Skewing the Immune Response Either toward Help for B Cells and a Sustained Autoantibody Response or toward Help for CD8 T Cells and a Downregulatory Th1 Response.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Dendritic cells in Leishmania major infections: mechanisms of parasite uptake, cell activation and evidence for physiological relevance.Medical microbiology and immunology · 2012Review
- A role for leukocyte-derived IL-1RA in DC homeostasis revealed by increased susceptibility of IL-1RA-deficient mice to cutaneous leishmaniasis.The Journal of investigative dermatology · 2011Article
- IL-1 signalling is dispensable for protective immunity in Leishmania-resistant mice.Experimental dermatology · 2011Article
- Gene expression profiling of dendritic cells reveals important mechanisms associated with predisposition to Staphylococcus infections.PloS one · 2011Article
- Direct visualization of peptide/MHC complexes at the surface and in the intracellular compartments of cells infected in vivo by Leishmania major.PLoS pathogens · 2010Article
- Keratinocytes determine Th1 immunity during early experimental leishmaniasis.PLoS pathogens · 2010Article
- Miltefosine efficiently eliminates Leishmania major amastigotes from infected murine dendritic cells without altering their immune functions.Antimicrobial agents and chemotherapy · 2010Article
- Tumor antigen cross-presentation and the dendritic cell: where it all begins?Clinical & developmental immunology · 2010Article
- Dendritic cell subsets in primary and secondary T cell responses at body surfaces.Nature immunology · 2009Review
- IL-17 promotes progression of cutaneous leishmaniasis in susceptible mice.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Protective CD8 T cells against Plasmodium liver stages: immunobiology of an 'unnatural' immune response.Immunological reviews · 2008Review
- Alphavirus replicon particles acting as adjuvants promote CD8+ T cell responses to co-delivered antigen.Vaccine · 2008Article
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resistance and susceptibility to Leishmania major in mice are determined by multiple genes and correlate with the preferential development of Th1 and Th2 responses, respectively. Here, we found that CD11b+ dendritic cells (DCs) prime parasite-specific CD4+ T cells in both susceptible BALB/c (H2-d) and resistant B10.D2 (H2-d) mice. However, BALB/c and B10.D2 DCs from L. major-infected mice differ in their ability to polarize naive T cells into Th1 or Th2 effector cells. This difference is cell-intrinsic, is not restricted to H2-d mice, and is observed with both parasite-specific and allospecific CD4+ T cells. Thus, strain-specific differences within CD11b+ DCs influence the ability of inbred mice to mount polarized CD4+ T cell responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.