Evidence map›Paper›PMID 12858208›Full record

ArticleBone marrow transplantation2003

Complete remission of Crohn's disease after high-dose cyclophosphamide and autologous stem cell transplantation.

W Kreisel, K Potthoff, H Bertz, A Schmitt-Graeff, G Ruf, J Rasenack, J Finke

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Bone marrow transplantation, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 5 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 5 syntheses or guidelines pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Guideline
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Stem cell autograft and allograft in autoimmune diseases.Clinical and experimental medicine · 2016
    Review
  12. Stem cell therapy for inflammatory bowel disease.Journal of gastroenterology · 2015
    Review
  13. Review
  14. Article
  15. Intestinal stem cells and epithelial-mesenchymal interactions in the crypt and stem cell niche.Translational research : the journal of laboratory and clinical medicine · 2010
    Review
  16. Article
  17. Review
  18. Review
  19. Management of Perianal Crohn's Disease.Current treatment options in gastroenterology · 2005
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

W KreiselMedical Clinic, Department of Gastroenterology, Hepatology and Endocrinology, University of Freiburg, Freiburg, Germany.
K Potthoff
H Bertz
A Schmitt-Graeff
G Ruf
J Rasenack
J Finke
University of Freiburg · DEUniversity Medical Center Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a 36-year-old male with ileocolic Crohn's disease (CD) no long-lasting remission was obtained by treatment with corticosteroids, mesalazine, azathioprine and antibiotics. Surgical interventions due to relapsing fistulae and abscesses resulted in the removal of >1.5 m of small bowel and left only 40 cm of large bowel. In July 2000, a new fistula and abscess developed. The combination of corticosteroids, mesalazine, ciprofloxacin, metronidazol, azathioprine, formula diet and anti-TNF-alpha antibody largely reduced clinical activity, and resection of fistula and abscess were successful. Despite clinical remission, histology showed activity in the small bowel and the colon. In March 2001, stem cell mobilization chemotherapy with cyclophosphamide was performed. It induced an endoscopic remission for 9 months, which was maintained on azathioprine and corticosteroids. After relapse, in March 2002, high-dose chemotherapy with cyclophosphamide and reinfusion of T-cell-depleted autologous peripheral CD34+ blood stem cells were performed. This led to a complete clinical, endoscopical and histological remission for 9 months without any treatment. Thereafter, endoscopy showed initial aphthous lesions with minimal histological signs of inflammation. The patient is asymptomatic, but low-dose prednisolone and methotrexate are prophylactically given. Immunoablative chemotherapy followed by autologous peripheral blood stem cell transplantation may be a beneficial therapeutic option in complicated refractory CD.

Indexed as

Hematopoietic Stem Cell TransplantationAdultCrohn DiseaseCyclophosphamideHumansImmunosuppressive AgentsMaleRemission InductionSalvage TherapyTransplantation, AutologousTreatment OutcomeCyclophosphamideImmunosuppressive Agents

Identifiers

PMID12858208
OpenAlexW2054104356

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.