ReviewImmunologic research2003
Positive and negative selection during B lymphocyte development.
Review in Immunologic research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 43 citations in OpenAlex.
- Calcium Signaling: From Normal B Cell Development to Tolerance Breakdown and Autoimmunity.Clinical reviews in allergy & immunology · 2017Review
- B-CD8Journal of immunology research · 2017Article
- Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.Cell death and differentiation · 2016Article
- The BAFFling function of Syk in B-cell homeostasis.The EMBO journal · 2015Article
- Midkine as a regulator of B cell survival in health and disease.British journal of pharmacology · 2014Review
- Stochastic gene expression in mammals: lessons from olfaction.Trends in cell biology · 2013Review
- A single mid-gestation exposure to TCDD yields a postnatal autoimmune signature, differing by sex, in early geriatric C57BL/6 mice.Toxicology · 2011Article
- Human immune system mice: current potential and limitations for translational research on human antibody responses.Immunologic research · 2011Article
- T. brucei infection reduces B lymphopoiesis in bone marrow and truncates compensatory splenic lymphopoiesis through transitional B-cell apoptosis.PLoS pathogens · 2011Article
- The adaptor molecule Act1 regulates BAFF responsiveness and self-reactive B cell selection during transitional B cell maturation.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- The role of B cells in lupus pathogenesis.The international journal of biochemistry & cell biology · 2010Review
- Article
- Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus.Arthritis research & therapy · 2006Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our laboratory is interested in a variety of issues related to lymphocyte development. More specifically, we have focused on the processes that regulate the decision to commit to the B lymphocyte (B cell) lineage, then the subsequent signals that are involved in maintaining this commitment to the B cell lineage. These signals result in the positive selection of those B cells that properly execute the complex genetic changes associated with B cell development, then trigger the elimination of B cells that are responsive to self-antigens and, therefore, possess the potential to mediate autoimmune disease. Our general experimental approach has been to address these issues from the perspective of signal transduction. Our goal is to define the biochemical and genetic processes that are integrated in order to accomplish these selection processes. To do so, we employ in vivo animal models as well as more defined in vitro studies, using both primary and transformed cell lines. For the past several years, we have been primarily interested in the precise mechanisms by which the B cell antigen receptor (BCR), and intermediate forms of this receptor, regulate these complex developmental processes. We have used the ongoing studies described below as two representative examples of how we are approaching these issues and some of the insights that we have made. To place both of these studies in context, we will begin with a brief introduction into B cell development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.