Evidence map›Paper›PMID 12857981›Full record

ReviewImmunologic research2003

Regulation of hematopoietic cell development and activation by adapter proteins.

Gary A Koretzky, Farhad Abtahian, Geo S Derimanov, Sally A Dmowski, Anastasia Guerriero, Martha S Jordan, Jonathan S Maltzman, Benjamin A Olenchock, Andrew L Singer, Jennifer N Wu and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Immunologic research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Gary A KoretzkyAbramson Family Cancer Research Institute, Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Farhad Abtahian
Geo S Derimanov
Sally A Dmowski
Anastasia Guerriero
Martha S Jordan
Jonathan S Maltzman
Benjamin A Olenchock
Andrew L Singer
Jennifer N Wu
Xiao-Ping Zhong
Cancer Research Institute · USUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adapter proteins, molecules with modular domains that mediate intermolecular interactions, play critical roles in the regulation of signaling events in all cell types. A major focus of our laboratory has been to examine the role of adapter molecules in hematopoietic cell development and activation. This review will describe the approaches we are taking to identify such proteins and to determine the mechanisms by which they exert their functions. This work represents the enormous efforts of the students and postdocs who have committed themselves to these projects, as well as the important collaborations we have developed with other investigators at the University of Pennsylvania and elsewhere.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsHematopoiesisHumansPhosphoproteinsSignal TransductionT-LymphocytesAdaptor Proteins, Signal TransducingPhosphoproteinsSLP-76 signal Transducing adaptor proteins

Identifiers

PMID12857981
OpenAlexW1988797828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.