ArticleProceedings of the National Academy of Sciences of the United States of America2003
Shape bistability of a membrane neck: a toggle switch to control vesicle content release.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Bimodal Mechanical Response of Membrane Necks: Implications for the Nuclear Envelope.ACS nano · 2026Article
- Formation of Multispheres and Myelin Based on Multiple Solutions of Membrane Shape Equation.Membranes · 2025Article
- Dynamin-like Proteins Combine Mechano-constriction and Membrane Remodeling to Enable Two-Step Mitochondrial Fission via a "Snap-through" Instability.Journal of the American Chemical Society · 2025Article
- Human Immunodeficiency Virus Type 1 Gag Polyprotein Modulates Membrane Physical Properties like a Surfactant: Potential Implications for Virus Assembly.ACS infectious diseases · 2024Article
- Molecular Sensing and Manipulation of Protein Oligomerization in Membrane Nanotubes with Bolaamphiphilic Foldamers.Journal of the American Chemical Society · 2023Article
- Three membrane fusion pore families determine the pathway to pore dilation.Biophysical journal · 2023Article
- Inhomogeneous Canham-Helfrich Abscission in Catenoid Necks under Critical Membrane Mosaicity.Membranes · 2023Article
- Membrane Lipid Reshaping Underlies Oxidative Stress Sensing by the Mitochondrial Proteins UCP1 and ANT1.Antioxidants (Basel, Switzerland) · 2022Article
- Molecular Shape Solution for Mesoscopic Remodeling of Cellular Membranes.Annual review of biophysics · 2022Review
- Nonlinear material and ionic transport through membrane nanotubes.Biochimica et biophysica acta. Biomembranes · 2021Article
- Reconstitution and real-time quantification of membrane remodeling by single proteins and protein complexes.Nature protocols · 2020Article
- Combining patch-clamping and fluorescence microscopy for quantitative reconstitution of cellular membrane processes with Giant Suspended Bilayers.Scientific reports · 2019Article
- A novel fluorescence microscopic approach to quantitatively analyse protein-induced membrane remodelling.Journal of biosciences · 2018Review
- Amperometry methods for monitoring vesicular quantal size and regulation of exocytosis release.Pflugers Archiv : European journal of physiology · 2018Review
- Use of the supported membrane tube assay system for real-time analysis of membrane fission reactions.Nature protocols · 2017Article
- Synthesis, lipid membrane incorporation, and ion permeability testing of carbon nanotube porins.Nature protocols · 2016Article
- Cholesterol Alters the Dynamics of Release in Protein Independent Cell Models for Exocytosis.Scientific reports · 2016Article
- Stochastic transport through carbon nanotubes in lipid bilayers and live cell membranes.Nature · 2014Article
- Geometric catalysis of membrane fission driven by flexible dynamin rings.Science (New York, N.Y.) · 2013Article
- Membrane-elasticity model of Coatless vesicle budding induced by ESCRT complexes.PLoS computational biology · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Shape dynamics and permeability of a membrane neck connecting a vesicle and plasma membrane are considered. The neck is modeled by a lipid membrane tubule extended between two parallel axisymmetric rings. Within a range of lengths, defined by system geometry and mechanical properties of the membrane, the tubule has two stable shapes: catenoidal microtubule and cylindrical nanotubule. The permeabilities of these two shapes, measured as ionic conductivity of the tubule interior, differ by up to four orders of magnitude. Near the critical length the transitions between the shapes occur within less than a millisecond. Theoretical estimates show that the shape switching is controlled by a single parameter, the tubule length. Thus the tubule connection can operate as a conductivity microswitch, toggling the release of vesicle content in such cellular processes as "kiss-and-run" exocytosis. In support of this notion, bistable behavior of membrane connections between vesicles and the cell plasma membrane in macrophages is demonstrated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.