ArticleJournal of virology2003
Hantavirus-specific CD8(+)-T-cell responses in newborn mice persistently infected with Hantaan virus.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Investigation of a subunit protein vaccine for HFRS based on a consensus sequence between envelope glycoproteins of HTNV and SEOV.Virus research · 2023Article
- Pathological Studies on Hantaan Virus-Infected Mice Simulating Severe Hemorrhagic Fever with Renal Syndrome.Viruses · 2022Article
- Comparative Immunoreactivity Analyses of Hantaan Virus Glycoprotein-Derived MHC-I Epitopes in Vaccination.Vaccines · 2022Article
- Common Themes in Zoonotic Spillover and Disease Emergence: Lessons Learned from Bat- and Rodent-Borne RNA Viruses.Viruses · 2021Review
- Immunological Responses to Seoul Orthohantavirus in Experimentally and Naturally Infected Brown Rats (Viruses · 2021Article
- Article
- Design and synthesis of HLA-A*02-restricted Hantaan virus multiple-antigenic peptide for CD8Virology journal · 2020Article
- Comparison of Lymphocyte Populations in Patients With Dobrava or Puumala orthohantavirus Infection.Frontiers in cellular and infection microbiology · 2020Article
- T-Cell Response to Viral Hemorrhagic Fevers.Vaccines · 2019Review
- Appearance of renal hemorrhage in adult mice after inoculation of patient-derived hantavirus.Virology journal · 2017Article
- Novel Identified HLA-A*0201-Restricted Hantaan Virus Glycoprotein Cytotoxic T-Cell Epitopes Could Effectively Induce Protective Responses in HLA-A2.1/KFrontiers in immunology · 2017Article
- Animal Models for the Study of Rodent-Borne Hemorrhagic Fever Viruses: Arenaviruses and Hantaviruses.BioMed research international · 2015Review
- Levels of HTNV-specific CD8+ T lymphocytes in PBMC from the patients with hemorrhagic fever with renal syndrome.Internal and emergency medicine · 2013Article
- Highly differentiated, resting gn-specific memory CD8+ T cells persist years after infection by andes hantavirus.PLoS pathogens · 2010Article
- HSP70 induced by Hantavirus infection interacts with viral nucleocapsid protein and its overexpression suppresses virus infection in Vero E6 cells.American journal of translational research · 2009Article
- The detection of sLFA-3 in plasma of patients with hemorrhagic fever with renal syndrome.Clinical and experimental medicine · 2009Article
- Immunological mechanisms mediating hantavirus persistence in rodent reservoirs.PLoS pathogens · 2008Review
- Immunopathogenesis of hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome: Do CD8+ T cells trigger capillary leakage in viral hemorrhagic fevers?Immunology letters · 2007Article
- Regulatory T cells enhance persistence of the zoonotic pathogen Seoul virus in its reservoir host.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Cell fusion activities of Hantaan virus envelope glycoproteins.Journal of virology · 2004Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The relationship between virus-specific CD8(+)-T-cell responses and viral persistence was studied in mice by using Hantaan virus (HTNV). We first established a simple method for measuring levels of virus-specific CD8(+) T cells by flow cytometry. Next, to produce a mouse model of persistent HTNV infection, newborn mice were inoculated subcutaneously within 24 h of birth with 1 or 0.1 50% newborn mouse lethal dose of HTNV. All mice that escaped lethal infection were persistently infected with HTNV until at least 30 days after virus inoculation and had no virus-specific CD8(+) T cells producing gamma interferon (IFN-gamma). Subsequently, the virus was eliminated from some of the mice, depending on the appearance of functional virus-specific CD8(+) T cells, which have the ability to produce IFN-gamma and tumor necrosis factor alpha (TNF-alpha) and have cytotoxic activity. Neutralizing antibodies were detected in all mice, regardless of the presence or absence of virus. In the acute phase, which occurs within 30 days of infection, IFN-gamma-producing HTNV-specific CD8(+) T cells were detected on day 15 after virus inoculation. However, TNF-alpha production and the cytotoxic activity of these specific CD8(+) T cells were impaired and HTNV was not removed. Almost all of these specific CD8(+) T cells disappeared by day 18. These results suggest that functional HTNV-specific CD8(+) T cells are important for clearance of HTNV.
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