ArticleMolecular biology of the cell2003
Three-dimensional organization of basal bodies from wild-type and delta-tubulin deletion strains of Chlamydomonas reinhardtii.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
56 citing papers in PubMed, 154 citations in OpenAlex.
- Centrosome-Signaling Pathway Crosstalk: A Core Hub From Cellular Homeostasis to Disease.Cytoskeleton (Hoboken, N.J.) · 2026Review
- Delta tubulin stabilizes male meiotic kinetochores and aids microtubule remodeling and fertility.The Journal of cell biology · 2025Article
- Loss of an extensive ciliary connectome induces proteostasis and cell fate switching in a severe motile ciliopathy.bioRxiv : the preprint server for biology · 2024Article
- A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans.The EMBO journal · 2023Article
- Extensive programmed centriole elimination unveiled inScience advances · 2023Article
- CPAP insufficiency leads to incomplete centrioles that duplicate but fragment.The Journal of cell biology · 2022Article
- Review
- WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity.eLife · 2020Article
- Electron tomography reveals aspects of spindle structure important for mechanical stability at metaphase.Molecular biology of the cell · 2020Article
- Axonemal doublet microtubules can split into two complete singlets in human sperm flagellum tips.FEBS letters · 2019Article
- Coordination of eukaryotic cilia and flagella.Essays in biochemistry · 2018Review
- Cell polarity: having and making sense of direction-on the evolutionary significance of the primary cilium/centrosome organ in Metazoa.Open biology · 2018Review
- Review
- An orphan kinesin controls trypanosome morphology transitions by targeting FLAM3 to the flagellum.PLoS pathogens · 2018Article
- A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.Nature genetics · 2018Article
- Centrioles initiate cilia assembly but are dispensable for maturation and maintenance inThe Journal of cell biology · 2017Article
- Open Sesame: How Transition Fibers and the Transition Zone Control Ciliary Composition.Cold Spring Harbor perspectives in biology · 2017Review
- Mitosis.Cold Spring Harbor perspectives in biology · 2016Review
- Cilium transition zone proteome reveals compartmentalization and differential dynamics of ciliopathy complexes.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole.Nature communications · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Improved methods of specimen preparation and dual-axis electron tomography have been used to study the structure and organization of basal bodies in the unicellular alga Chlamydomonas reinhardtii. Novel structures have been found in both wild type and strains with mutations that affect specific tubulin isoforms. Previous studies have shown that strains lacking delta-tubulin fail to assemble the C-tubule of the basal body. Tomographic reconstructions of basal bodies from the delta-tubulin deletion mutant uni3-1 have confirmed that basal bodies contain mostly doublet microtubules. Our methods now show that the stellate fibers, which are present only in the transition zone of wild-type cells, repeat within the core of uni3-1 basal bodies. The distal striated fiber is incomplete in this mutant, rootlet microtubules can be misplaced, and multiflagellate cells have been observed. A suppressor of uni3-1, designated tua2-6, contains a mutation in alpha-tubulin. tua2-6; uni3-1 cells build both flagella, yet they retain defects in basal body structure and in rootlet microtubule positioning. These data suggest that the presence of specific tubulin isoforms in Chlamydomonas directly affects the assembly and function of both basal bodies and basal body-associated structures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.