ArticleMolecular biology of the cell2003
Directed motion of telomeres in the formation of the meiotic bouquet revealed by time course and simulation analysis.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
- Rewiring for movements in meiotic prophase: regulators, roles, and evolutionary pathways.Current opinion in genetics & development · 2025Review
- Rapid meiotic prophase chromosome movements in Arabidopsis thaliana are linked to essential reorganization at the nuclear envelope.Nature communications · 2024Article
- Formation and resolution of meiotic chromosome entanglements and interlocks.Journal of cell science · 2024Review
- Celebrating Mendel, McClintock, and Darlington: On end-to-end chromosome fusions and nested chromosome fusions.The Plant cell · 2022Review
- Bouquet Formation Failure in Meiosis of FPlants (Basel, Switzerland) · 2022Article
- Telomeres and Subtelomeres Dynamics in the Context of Early Chromosome Interactions During Meiosis and Their Implications in Plant Breeding.Frontiers in plant science · 2021Review
- The dissection of meiotic chromosome movement in mice using an in vivo electroporation technique.PLoS genetics · 2014Article
- Quantitative dynamics of telomere bouquet formation.PLoS computational biology · 2012Article
- Modeling meiotic chromosomes indicates a size dependent contribution of telomere clustering and chromosome rigidity to homologue juxtaposition.PLoS computational biology · 2012Article
- Maize meiotic mutants with improper or non-homologous synapsis due to problems in pairing or synaptonemal complex formation.Journal of experimental botany · 2011Article
- The Arabidopsis nuclear pore and nuclear envelope.The arabidopsis book · 2010Article
- From early homologue recognition to synaptonemal complex formation.Chromosoma · 2006Review
- Meiotic telomere clustering requires actin for its formation and cohesin for its resolution.The Journal of cell biology · 2005Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Chromosome movement is critical for homologous chromosome pairing during meiosis. A prominent and nearly universal meiotic chromosome reorganization is the formation of the bouquet, characterized by the close clustering of chromosome ends at the nuclear envelope. We have used a novel method of in vitro culture of rye anthers combined with fluorescent in situ hybridization (FISH) detection of telomeres to quantitatively study bouquet formation. The three-dimensional distribution of telomeres over time was used to obtain a quantitative profile of bouquet formation intermediates. The bouquet formed through a gradual, continuous tightening of telomeres over approximately 6 h. To determine whether the motion of chromosomes was random or directed, we developed a computer simulation of bouquet formation to compare with our observations. We varied the diffusion rate of telomeres and the amount of directional bias in telomere movement. In our models, the bouquet was formed in a manner comparable to what we observed in cultured meiocytes only when the movement of telomeres was actively directed toward the bouquet site, whereas a wide range of diffusion rates were permitted. Directed motion, as opposed to random diffusion, was required to reproduce our observations, implying that an active process moves chromosomes to cause telomere clustering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.