ReviewClinical microbiology reviews2003
Biology and pathogenesis of thrombosis and procoagulant activity in invasive infections caused by group A streptococci and Clostridium perfringens.
Review in Clinical microbiology reviews, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 102 citations in OpenAlex.
- Ischemic dermal pallor as an unusual cutaneous clue for group A streptococcal necrotizing soft tissue infection.JAAD case reports · 2026Article
- Repurposing caspofungin as a small-molecule inhibitor of Clostridium perfringens α-toxin for treatment of gas gangrene.Communications medicine · 2026Article
- Article
- Clinical characteristics and predictive factors of thrombotic complications in children with acute mastoiditis: a single center retrospective study.European journal of pediatrics · 2025Article
- Repositioning of anti-infective compounds against monkeypox virus core cysteine proteinase: a molecular dynamics study.Molecular diversity · 2024Article
- Role of systemic immune-inflammatory index and systemic inflammatory response index in predicting the diagnosis of necrotizing pneumonia in children.BMC pediatrics · 2024Article
- Real-time identification of life-threatening necrotizing soft-tissue infections using indocyanine green fluorescence imaging.Journal of biomedical optics · 2024Observational
- Article
- Osteomyelitis of the Jaw in COVID-19 Patients: A Rare Condition With a High Risk for Severe Complications.Frontiers in surgery · 2022Article
- Toll-Like Receptor 4 Protects AgainstFrontiers in cellular and infection microbiology · 2021Article
- Review
- Virus-induced genetics revealed by multidimensional precision medicine transcriptional workflow applicable to COVID-19.Physiological genomics · 2020Article
- Article
- Histotoxic Clostridial Infections.Microbiology spectrum · 2019Article
- Article
- Circular RNA expression profile of spleen in aFEBS open bio · 2018Article
- Morphological Observation and Comparative Transcriptomic Analysis of Clostridium perfringens Biofilm and Planktonic Cells.Current microbiology · 2018Article
- Mechanisms of Action and Cell Death Associated withToxins · 2018Review
- Associations of the plasma lipidome with mortality in the acute respiratory distress syndrome: a longitudinal cohort study.Respiratory research · 2018Observational
- Analyses of long non-coding RNA and mRNA profiling in the spleen of diarrheic piglets caused byPeerJ · 2018Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Group A streptococcal necrotizing fasciitis/myonecrosis and Clostridium perfringens gas gangrene are two of the most fulminant gram-positive infections in humans. Tissue destruction associated with these infections progresses rapidly to involve an entire extremity. Multiple-organ failure is common, and morbidity and mortality remain high. Systemic activation of coagulation and dysregulation of the anticoagulation pathways contribute to the pathogenesis of many diverse disease entities of infectious etiology, and it has been our hypothesis that microvascular thrombosis contributes to reduced tissue perfusion, hypoxia, and subsequent regional tissue necrosis and organ failure in these invasive gram-positive infections. This article reviews the coagulation, anticoagulation, and fibrinolytic systems from cellular players to cytokines to novel antithrombotic therapies and discusses the mechanisms contributing to occlusive microvascular thrombosis and tissue destruction in invasive group A streptococcal and C. perfringens infections. A thorough understanding of these mechanisms may suggest novel therapeutic targets for patients with these devastating infections.
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