ArticleClinical & experimental metastasis2003
MDA-MB-435 human breast carcinoma metastasis to bone.
Article in Clinical & experimental metastasis, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 60 citations in OpenAlex.
- Dissecting metastasis using preclinical models and methods.Nature reviews. Cancer · 2023Review
- Activation of the HNRNPA2B1/Journal of Cancer · 2023Article
- PIM3 kinase promotes tumor metastasis in hepatoblastoma by upregulating cell surface expression of chemokine receptor cxcr4.Clinical & experimental metastasis · 2022Article
- Loss of microRNA-135b Enhances Bone Metastasis in Prostate Cancer and Predicts Aggressiveness in Human Prostate Samples.Cancers · 2021Article
- Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2Breast cancer research : BCR · 2019Article
- Article
- Label-free Raman spectroscopy provides early determination and precise localization of breast cancer-colonized bone alterations.Chemical science · 2018Article
- Animal and cellular models of hepatocellular carcinoma bone metastasis: establishment and characterisation.Journal of cancer research and clinical oncology · 2015Article
- Application of GFP imaging in cancer.Laboratory investigation; a journal of technical methods and pathology · 2015Review
- Unraveling the role of KIAA1199, a novel endoplasmic reticulum protein, in cancer cell migration.Journal of the National Cancer Institute · 2013Article
- Rebuilding cancer metastasis in the mouse.Molecular oncology · 2013Review
- A cross-species analysis of a mouse model of breast cancer-specific osteolysis and human bone metastases using gene expression profiling.BMC cancer · 2011Article
- Pre-osteoblastic MC3T3-E1 cells promote breast cancer growth in bone in a murine xenograft model.Chinese journal of cancer · 2011Article
- Arming a replicating adenovirus with osteoprotegerin reduces the tumor burden in a murine model of osteolytic bone metastases of breast cancer.Cancer gene therapy · 2010Article
- Individual and combined soy isoflavones exert differential effects on metastatic cancer progression.Clinical & experimental metastasis · 2010Article
- Notch3 in human breast cancer cell lines regulates osteoblast-cancer cell interactions and osteolytic bone metastasis.The American journal of pathology · 2010Article
- Extracellular engagement of alpha6 integrin inhibited urokinase-type plasminogen activator-mediated cleavage and delayed human prostate bone metastasis.Cancer research · 2009Article
- Inhibition of CXCR4 by CTCE-9908 inhibits breast cancer metastasis to lung and bone.Oncology reports · 2009Article
- Modulation of prostate cancer cell gene expression by cell-to-cell contact with bone marrow stromal cells or osteoblasts.Clinical & experimental metastasis · 2009Article
- Human Cell Surface Receptors as Molecular Imaging Candidates for Metastatic Prostate Cancer.The open prostate cancer journal · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Breast cancer metastasizes to bone with high frequency and incidence. However, studies of breast cancer metastasis to bone have been limited by two factors. First, the number of models that colonize bone are limited. Second, detection of bone metastases is too insensitive or too laborious for routine, large-scale studies or for studying the earliest steps in bone colonization. To partially alleviate these problems, the highly metastatic MDA-MB-435 (435) human breast carcinoma cell line was engineered to constitutively express enhanced green fluorescent protein (GFP). While 435GFP cells did not form femoral metastases following orthotopic or intravenous injections, they produced widespread osteolytic skeletal metastases following injection into the left ventricle of the heart. All mice developed at least one femur metastasis as well as a mandibular metastasis. As in humans, osseous metastases localized predominantly to trabecular regions, especially proximal and distal femur, proximal tibia, proximal humerus and lumbar vertebrae. 435GFP cells also developed metastases in adrenal glands, brain and ovary following intracardiac injection, suggesting that this model may also be useful for studying organotropism to other tissues as well. Additionally, GFP-tagging permitted detection of single cells and microscopic metastases in bone at early time points following arrival and at stages of proliferation prior to coalescence of individual metastases.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.