ArticleClinical & experimental metastasis2003
Activation of c-Met in colorectal carcinoma cells leads to constitutive association of tyrosine-phosphorylated beta-catenin.
Article in Clinical & experimental metastasis, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Study of ß-catenin signaling pathway modulated by PTHrP in cell and animal colorectal cancer models.Frontiers in oncology · 2026Article
- Decorin as a multivalent therapeutic agent against cancer.Advanced drug delivery reviews · 2016Review
- eXamine: exploring annotated modules in networks.BMC bioinformatics · 2014Article
- Family-wide investigation of PDZ domain-mediated protein-protein interactions implicates β-catenin in maintaining the integrity of tight junctions.Chemistry & biology · 2013Article
- Wnt/β-catenin signaling is a key downstream mediator of MET signaling in glioblastoma stem cells.Neuro-oncology · 2013Article
- Meeting the biologic challenge of colorectal metastases.Clinical & experimental metastasis · 2012Review
- Cooperative interaction of MUC1 with the HGF/c-Met pathway during hepatocarcinogenesis.Molecular cancer · 2012Article
- Decorin: a guardian from the matrix.The American journal of pathology · 2012Review
- Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.Journal of cellular and molecular medicine · 2011Review
- Article
- Beta-catenin signaling involves HGF-enhanced HepG2 scattering through activating MMP-7 transcription.Histochemistry and cell biology · 2010Article
- Targeting the Met signaling pathway in renal cancer.Expert review of anticancer therapy · 2009Review
- Decorin is a novel antagonistic ligand of the Met receptor.The Journal of cell biology · 2009Article
- Not so simple: the complexity of phosphotyrosine signaling at cadherin adhesive contacts.Journal of molecular medicine (Berlin, Germany) · 2007Review
- A positive feedback loop between hepatocyte growth factor receptor and beta-catenin sustains colorectal cancer cell invasive growth.Oncogene · 2007Article
- Alternative splicing and differential gene expression in colon cancer detected by a whole genome exon array.BMC genomics · 2006Article
- The von Hippel-Lindau tumor suppressor gene product represses oncogenic beta-catenin signaling in renal carcinoma cells.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Modulation of E-cadherin by hepatocyte growth factor induces aggressiveness of gastric carcinoma.Annals of surgery · 2005Article
- Insulinlike growth factor-I-mediated migration and invasion of human colon carcinoma cells requires activation of c-Met and urokinase plasminogen activator receptor.Annals of surgery · 2005Article
- MET signalling in primary colon epithelial cells leads to increased transformation irrespective of aberrant Wnt signalling.British journal of cancer · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Increased expression and/or activity of c-Met, the receptor protein tyrosine kinase for hepatocyte growth factor/scatter factor, occurs commonly during colon tumor progression. To examine potential roles for c-Met in promoting metastasis, we compared the colon tumor cell line KM12C with low metastatic potential to the isogenic variants KM,12L4 and KM12SM with high metastatic potential. KM12C cells express c-Met with low levels of tyrosine phosphorylation in the absence of HGF. The high metastatic cells express a c-Met that is constitutively tyrosine phosphorylated, they have increased colony formation, and are minimally responsive to HGF relative to the parental cells. Tyrosine-phosphorylated beta-catenin was constitutively associated with c-Met in the more metastatic cells, but was inducible only after HGF addition in the less metastatic cells. Functions mediated by beta-catenin, including cell-cell adhesion and migration, and activation of the tcf (T-cell factor) family of transcription factors, were also elevated in the more metastatic KM12SM and L4 cells. Furthermore, analysis of the known tcf transcriptional target genes, cyclin D1, c-Myc, and uPAR, demonstrated increased expression in the high metastatic cells, correlating with the levels of tcf activity. Collectively, these results suggest that endogenous activation of c-Met in highly metastatic KM12SM CRC cells results in increased survival and growth under anchorage independent conditions, increased in vitro migration, and elevated levels of tcf target genes. Thus, beta-catenin association with activated c-Met may contribute to a more aggressive liver metastatic phenotype of these cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.