ArticleMammalian genome : official journal of the International Mammalian Genome Society2003
Loci on chromosomes 2, 4, 9, and 16 for body weight, body length, and adiposity identified in a genome scan of an F2 intercross between the 129P3/J and C57BL/6ByJ mouse strains.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 52 citations in OpenAlex.
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- Systems Genetics of Hepatic Metabolome Reveals Octopamine as a Target for Non-Alcoholic Fatty Liver Disease Treatment.Scientific reports · 2019Article
- Burly1 is a mouse QTL for lean body mass that maps to a 0.8-Mb region of chromosome 2.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- C57BL/6J mice as a polygenic developmental model of diet-induced obesity.Physiological reports · 2017Article
- Adiposity QTL Adip20 decomposes into at least four loci when dissected using congenic strains.PloS one · 2017Article
- Genetic Regulation of Female Sexual Maturation and Longevity Through Circulating IGF1.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Body Composition QTLs Identified in Intercross Populations Are Reproducible in Consomic Mouse Strains.PloS one · 2015Article
- Linking cellular zinc status to body weight and fat mass: mapping quantitative trait loci in Znt7 knockout mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Article
- QTL analysis of dietary obesity in C57BL/6byj X 129P3/J F2 mice: diet- and sex-dependent effects.PloS one · 2013Article
- Quantitative trait locus mapping of genes that control body length and plasma insulin-like growth factor 1 level in mice.BMC research notes · 2012Article
- Identification of exercise capacity QTL using association mapping in inbred mice.Physiological genomics · 2012Article
- Mouse models and type 2 diabetes: translational opportunities.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Review
- Body fat distribution and organ weights of 14 common strains and a 22-strain consomic panel of rats.Physiology & behavior · 2011Article
- Genetic dissection of intermale aggressive behavior in BALB/cJ and A/J mice.Genes, brain, and behavior · 2011Article
- Involvement of the calcium-sensing receptor in human taste perception.The Journal of biological chemistry · 2010Article
- Genetic loci that control the size of laser-induced choroidal neovascularization.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
- Gene discovery and the genetic basis of calcium consumption.Physiology & behavior · 2008Review
- Candidate genes for obesity revealed from a C57BL/6J x 129S1/SvImJ intercross.International journal of obesity (2005) · 2008Article
- QTL for body composition on chromosome 7 detected using a chromosome substitution mouse strain.Obesity (Silver Spring, Md.) · 2008Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Mice have proved to be a powerful model organism for understanding obesity in humans. Single gene mutants and genetically modified mice have been used to identify obesity genes, and the discovery of loci for polygenic forms of obesity in the mouse is an important next step. To pursue this goal, the inbred mouse strains 129P3/J (129) and C57BL/6ByJ (B6), which differ in body weight, body length, and adiposity, were used in an F2 cross to identify loci affecting these phenotypes. Linkages were determined in a two-phase process. In the first phase, 169 randomly selected F2 mice were genotyped for 134 markers that covered all autosomes and the X Chromosome (Chr). Significant linkages were found for body weight and body length on Chr 2. In addition, we detected several suggestive linkages on Chr 2 (adiposity), 9 (body weight, body length, and adiposity), and 16 (adiposity), as well as two suggestive sex-dependent linkages for body length on Chrs 4 and 9. In the second phase, 288 additional F2 mice were genotyped for markers near these regions of linkage. In the combined set of 457 F2 mice, six significant linkages were found: Chr 2 (Bwq5, body weight and Bdln3, body length), Chr 4 (Bdln6, body length, males only), Chr 9 (Bwq6, body weight and Adip5, adiposity), and Chr 16 (Adip9, adiposity), as well as several suggestive linkages (Adip2, adiposity on Chr 2, Bdln4 and Bdln5, body length on Chr 9). In addition, there was a suggestive linkage to body length in males on Chr 9 (Bdln4). For adiposity, there was evidence for epistatic interactions between loci on Chr 9 (Adip5) and 16 (Adip9). These results reinforce the concept that obesity is a complex trait. Genetic loci and their interactions, in conjunction with sex, age, and diet, determine body size and adiposity in mice.
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