ReviewBiology of reproduction2003
Nuclear receptor coactivator function in reproductive physiology and behavior.
Review in Biology of reproduction, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 52 citations in OpenAlex.
- Progesterone receptor is constitutively expressed in induced Pluripotent Stem Cells (iPSCs).Stem cell reviews and reports · 2024Article
- Article
- Steroids and the brain: 50years of research, conceptual shifts and the ascent of non-classical and membrane-initiated actions.Hormones and behavior · 2018Review
- Article
- Estrogenic plant extracts reverse weight gain and fat accumulation without causing mammary gland or uterine proliferation.PloS one · 2011Article
- Steroid receptor coactivator (SRC) family: masters of systems biology.The Journal of biological chemistry · 2010Review
- Isoform-specific degradation of PR-B by E6-AP is critical for normal mammary gland development.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Steroid receptor coactivator-1 from brain physically interacts differentially with steroid receptor subtypes.Endocrinology · 2008Article
- Sex steroid-related candidate genes in psychiatric disorders.Journal of psychiatry & neuroscience : JPN · 2008Review
- Cells in behaviourally relevant brain regions coexpress nuclear receptor coactivators and ovarian steroid receptors.Journal of neuroendocrinology · 2007Article
- Nuclear receptor coactivators function in estrogen receptor- and progestin receptor-dependent aspects of sexual behavior in female rats.Hormones and behavior · 2006Article
- Behavioral neuroendocrinology in nontraditional species of mammals: things the 'knockout' mouse CAN'T tell us.Hormones and behavior · 2005Review
- Nuclear receptor coregulators are new players in nervous system development and function.Molecular neurobiology · 2004Review
- Photoperiodic regulation of androgen receptor and steroid receptor coactivator-1 in Siberian hamster brain.Brain research. Molecular brain research · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Gonadal steroid hormones act throughout the body to elicit changes in gene expression that result in profound effects on reproductive physiology and behavior. Steroid hormones exert many of these effects by binding to their respective intracellular receptors, which are members of a nuclear receptor superfamily of transcriptional activators. A variety of in vitro studies indicate that nuclear receptor coactivators are required for efficient transcriptional activity of steroid receptors. Many of these coactivators are found in a variety of steroid hormone-responsive reproductive tissues, including the reproductive tract, mammary gland, and brain. While many nuclear receptor coactivators have been investigated in vitro, we are only now beginning to understand their function in reproductive physiology and behavior. In this review, we discuss the general mechanisms of action of nuclear receptor coactivators in steroid-dependent gene transcription. We then review some recent and exciting findings on the function of nuclear receptor coactivators in steroid-dependent brain development and reproductive physiology and behavior.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.