Evidence map›Paper›PMID 1285499›Full record

ArticleActa neuropathologica1992

Desmin and vimentin as markers of regeneration in muscle diseases.

A Gallanti, A Prelle, M Moggio, P Ciscato, N Checcarelli, M Sciacco, A Comini, G Scarlato

Abstract read
PubMed Publisher
In one paragraph

Article in Acta neuropathologica, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 91 citations in OpenAlex.

  1. Article
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  6. Article
  7. The evolution of vimentin and desmin inFrontiers in physiology · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
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  14. Article
  15. Article
  16. Overview of the Muscle Cytoskeleton.Comprehensive Physiology · 2017
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

A GallantiIstituto di Clinica Neurologica, Centro Dino Ferrari, Università degli Studi, Milano, Italy.
A Prelle
M Moggio
P Ciscato
N Checcarelli
M Sciacco
A Comini
G Scarlato
Istituto di Sessuologia Clinica · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Localization and distribution of desmin and vimentin have been studied in different neuromuscular disorders using monoclonal antibodies. We have demonstrated that vimentin, although virtually absent in normal human muscle fibers, is expressed in regenerating fibers in different neuromuscular disorders. Moreover, these fibers showed a strong positivity with desmin antibodies. In normal muscle fibers desmin is only localized at Z-line level. These results suggest that desmin and vimentin may be over-expressed during muscle regeneration processes, probably because of their importance in the structural organization of the sarcomere.

Indexed as

Antibodies, MonoclonalBiomarkersDesminFluorescent Antibody TechniqueHumansMuscular DiseasesRegenerationVimentinAntibodies, MonoclonalBiomarkersDesminVimentin

Identifiers

PMID1285499
OpenAlexW1992542653

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.