ArticleBMC anesthesiology2003
Oral valdecoxib and injected parecoxib for acute postoperative pain: a quantitative systematic review.
Article in BMC anesthesiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Intravenous or intramuscular parecoxib for acute postoperative pain in adults.The Cochrane database of systematic reviews · 2009Pooled it
- Trial
- Perioperative celecoxib administration for pain management after total knee arthroplasty - a randomized, controlled study.BMC musculoskeletal disorders · 2008Trial
- Constitutive cyclooxygenase-2 is involved in central nociceptive processes in humans.Anesthesiology · 2007Trial
- Intravenous parecoxib for acute postoperative pain in adults.The Cochrane database of systematic reviews · 2008Article
- Cardiovascular risk with cyclooxygenase inhibitors: general problem with substance specific differences?Naunyn-Schmiedeberg's archives of pharmacology · 2006Review
- Effect of valdecoxib pretreatment on pain and secondary hyperalgesia: a randomized controlled trial in healthy volunteers [ISRCTN05282752, NCT00260325].BMC anesthesiology · 2006Article
- Combination therapy using the cyclooxygenase-2 inhibitor Parecoxib and radioimmunotherapy in nude mice with small peritoneal metastases of colonic origin.Cancer immunology, immunotherapy : CII · 2006Article
- [Selective cyclooxygenase-2 inhibitors for postoperative pain therapy. Analgesic efficacy and adverse effects].Der Anaesthesist · 2004Review
- [Non-opioid analgesics for perioperative pain therapy. Risks and rational basis for use].Der Anaesthesist · 2004Review
- Individual patient meta-analysis of single-dose rofecoxib in postoperative pain.BMC anesthesiology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClinical trials suggest that cyclo-oxygenase-2 specific inhibitors (coxibs) are an effective treatment for acute postoperative pain. The aims of this systematic review were to examine the evidence for oral valdecoxib and injected parecoxib, and quantify efficacy and adverse effects.
methodsInformation from randomized, double-blind studies in acute postoperative pain was sought. The area under the pain relief versus time curve over four to six hours was dichotomized using validated equations to derive the proportion of patients with treatment and placebo with at least 50% pain relief over four to six hours and calculate the number-needed-to-treat (NNT). Information on duration of analgesia and adverse events was also collected.
resultsThe NNT for one patient to experience at least 50% relief over six hours following a single oral dose of valdecoxib 20 mg and 40 mg was 1.7 (1.4 to 2.0) and 1.6 (1.4 to 1.8) respectively. The NNT for one patient to have at least 50% relief over four to six hours with parecoxib 20 mg IV and 40 mg IV was 3.0 (2.3 to 4.1) and 2.3 (2.0 to 2.6) respectively. Mean time to remedication (weighted by trial size) was >24 hours with valdecoxib 40 mg, 8.7 hours with parecoxib 40 mg IV and 1.7 to 1.8 hours with placebo. There were no statistical differences between treatment and placebo for any adverse effect.
conclusionBoth oral valdecoxib and injected parecoxib are effective treatments for acute postoperative pain.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.