Trial reportWorld journal of gastroenterology2003
Effects of heparin on liver fibrosis in patients with chronic hepatitis B.
Trial report in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Effects of Anticoagulants on Experimental Models of Established Chronic Liver Diseases: A Systematic Review and Meta-Analysis.Canadian journal of gastroenterology & hepatology · 2020Pooled it
- Non-Anticoagulant Activities of Low Molecular Weight Heparins-A Review.Pharmaceuticals (Basel, Switzerland) · 2023Review
- The effect of intraurethral heparin on inflammation and spongiofibrosis in a rat model of experimentally induced urethral trauma.International urology and nephrology · 2023Article
- The Therapeutic Potential of Anticoagulation in Organ Fibrosis.Frontiers in medicine · 2022Review
- Extracellular histones stimulate collagen expressionWorld journal of gastroenterology · 2020Article
- Molecular Magnetic Resonance Imaging of Fibrin Deposition in the Liver as an Indicator of Tissue Injury and Inflammation.Investigative radiology · 2020Article
- Anticoagulation in the cirrhotic patient.JHEP reports : innovation in hepatology · 2019Review
- The Role of Anticoagulation in Treating Portal Hypertension.Current hepatology reports · 2018Review
- Changing common sense: Anti-platelet/coagulation therapy against cirrhosis.World journal of hepatology · 2015Article
- Low molecular weight heparin in portal vein thrombosis of cirrhotic patients: only therapeutic purposes?TheScientificWorldJournal · 2014Article
- Role of anticoagulant therapy in liver disease.Hepatology international · 2013Article
- Antifibrotic effect of heparin on liver fibrosis model in rats.World journal of gastrointestinal pharmacology and therapeutics · 2012Article
- Ginkgo biloba extract reverses CCl4-induced liver fibrosis in rats.World journal of gastroenterology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the effects of heparin on liver fibrosis in patients with chronic hepatitis B.
methodsFifty-two cases under study were divided into two groups, group A and group B. The two groups were given regular treatment and heparin/low molecular weight heparin (LMWH) treatment respectively. Hepatic functions, serum hyaluronic acid (HA) and type IV collagen levels were measured before and after the treatment, and six cases were taken liver biopsy twice.
resultsAfter treatment, hepatic functions became significantly better in both groups. Serum HA and type IV collagen levels in group B compared with group A, decreased significantly after treatment. Collagen proliferation also decreased in group B after treatment.
conclusionHeparin/LMWH can inhibit collagen proliferation in liver tissues with hepatitis B.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.