Trial reportWorld journal of gastroenterology2003
Density of Helicobacter pylori may affect the efficacy of eradication therapy and ulcer healing in patients with active duodenal ulcers.
Trial report in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Pre-treatment urea breath test results predict the efficacy of Helicobacter pylori eradication therapy in patients with active duodenal ulcers.World journal of gastroenterology · 2004Trial
- Best Treatment Options for Severe Helicobacter pylori Infections.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025Article
- A 'rich-get-richer' mechanism drives patchy dynamics and resistance evolution in antibiotic-treated bacteria.Molecular systems biology · 2024Article
- Treatment ofHeliyon · 2023Review
- Effect of gastric microbiota on quadrupleWorld journal of gastroenterology · 2021Article
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- Article
- Severe gastritis decreases success rate of Helicobacter pylori eradication.Wiener klinische Wochenschrift · 2016Article
- Helicobacter pylori virulence genes and host genetic polymorphisms as risk factors for peptic ulcer disease.Expert review of gastroenterology & hepatology · 2015Review
- Effect of bacterial and host factors on Helicobacter pylori eradication therapy.Expert opinion on therapeutic targets · 2015Review
- Relationship between tobacco, cagA and vacA i1 virulence factors and bacterial load in patients infected by Helicobacter pylori.PloS one · 2015Article
- Real-time PCR for diagnosing Helicobacter pylori infection in patients with upper gastrointestinal bleeding: comparison with other classical diagnostic methods.Journal of clinical microbiology · 2012Article
- The inoculum effect and band-pass bacterial response to periodic antibiotic treatment.Molecular systems biology · 2012Article
- 13C urea breath test for (Helicobacter pylori): determination of the optimal cut-off point in a Canadian community population.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2006Article
- Prominent role of gamma-glutamyl-transpeptidase on the growth of Helicobacter pylori.World journal of gastroenterology · 2004Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the association of pre-treatment Helicobacter pylori (H. pylori) density with bacterial eradication and ulcer healing rates in patients with active duodenal ulcer.
methodsOne hundred and four consecutive duodenal ulcer outpatients with H. pylori infection ascertained by gastric histopathology and (13)C-urea breath test (UBT) were enrolled in this study. H. pylori density was graded histologically according to the Sydney system (normal, mild, moderate, and marked). In each patient, lansoprazole (30 mg b.i.d.), clarithromycin (500 mg b.i.d.) and amoxicillin (1 g b.i.d.) were used for 1 week, then 30 mg lansoprazole once daily was continued for an additional 3 weeks. Follow-up endoscopy was performed at 4 weeks after completion of the therapy, and UBT was done at 4 and 8 weeks after completion of the therapy.
resultsThe H. pylori eradication rates were 88.9 %/100.0 %, 94.3 %/100.0 %, and 69.7 %/85.2 %; and the ulcer healing rates were 88.9 %/100.0 %, 94.3 %/100.0 %, and 63.6 %/77.8 % (intention-to-treat/per protocol analysis) in the mild, moderate, and marked H. pylori density groups, respectively. The association of pretreatment H. pylori density with the eradication rate and ulcer healing rate was both statistically significant (P=0.013/0.006 and 0.002/<0.001, respectively; using results of intention-to-treat/per protocol analysis).
conclusionIntragastric bacterial load may affect both the outcome of eradication treatment and ulcer healing in patients with active duodenal ulcer disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.