ArticleWorld journal of gastroenterology2003
Expression of survivin in human gastric carcinoma and gastric carcinoma model of rats.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Role of survivin as prognostic and clinicopathological marker in gastric cancer: a meta-analysis.Molecular biology reports · 2013Pooled it
- Mechanisms and applications of N-Methyl-N'-nitro-N-nitrosoguanidine in animal tumor models: current situation and challenges.Frontiers in oncology · 2025Review
- Survivin and XIAP expression in distinct tumor compartments of surgically resected gastric cancer: XIAP as a prognostic marker in diffuse and mixed type adenocarcinomas.Oncology letters · 2017Article
- DcR3 and survivin are highly expressed in colorectal carcinoma and closely correlated to its clinicopathologic parameters.Journal of Zhejiang University. Science. B · 2009Article
- The association between the survivin C-31G polymorphism and gastric cancer risk in a Chinese population.Digestive diseases and sciences · 2009Article
- Survivin expression in early hepatocellular carcinoma and post-treatment with anti-cancer drug under hypoxic culture condition.World journal of gastroenterology · 2007Article
- Downregulation of survivin by RNAi inhibits growth of human gastric carcinoma cells.World journal of gastroenterology · 2007Article
- Knockdown of survivin gene expression by RNAi induces apoptosis in human hepatocellular carcinoma cell line SMMC-7721.World journal of gastroenterology · 2005Article
- Survivin antisense compound inhibits proliferation and promotes apoptosis in liver cancer cells.World journal of gastroenterology · 2005Article
- Expression of survivin in primary and metastatic gastric cancer cells obtained by laser capture microdissection.World journal of gastroenterology · 2004Article
- Expression of survivin and its significance in colorectal cancer.World journal of gastroenterology · 2004Article
- Effects of bile reflux and intragastric microflora changes on lesions of remnant gastric mucosa after gastric operation.World journal of gastroenterology · 2004Article
- Survivin expression induced by doxorubicin in cholangiocarcinoma.World journal of gastroenterology · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the expression of survivin, an inhibitor of apoptosis protein, in human gastric carcinomas and gastric carcinoma models of rats.
methodsWith the method of immunohistochemical staining, we studied the expression of survivin in 20 cases of chronic gastritis and 56 cases of gastric carcinomas. We used N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and high dose sodium-chloride diet to induce rat gastric carcinomas. Survivin expression was studied in glandular stomachs of normal rats, adenocarcinomas and tissues adjacent to the tumor, as well as in rats during the induction period.
resultsSurvivin was expressed in 27 of 56 (48.2 %) cases of human gastric carcinoma tissues and 1 of 20 (5 %) cases of chronic gastritis. It was found that the expression of survivin had no relation with the elements of age, tumor depth, tumor size, and disease stage, but was significantly related to histological type. The positive rate of survivin expression in cases of intestinal type was significantly higher than that in cases of diffuse type (P<0.05). In animal experiments, survivin expression in glandular stomachs of normal rats, of rats in middle induction period, in adenocarcinomas and tissues adjacent to tumor were 0, 40.0 %, 78.3 % and 38.9 %, respectively. Compared with the survivin expression in normal rats, the differences were significant.
conclusionThese data imply that survivin plays an important role in the onset of gastric carcinoma and that high survivin expression is an early event of gastric carcinoma.
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