ArticleThe Journal of infectious diseases2003
Correlates of immune activation marker changes in human immunodeficiency virus (HIV)-seropositive and high-risk HIV-seronegative women who use illicit drugs.
Article in The Journal of infectious diseases, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000797 (Women's Interagency HIV Study), which is not on this map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Women's Interagency HIV Study (WIHS)
Who cites it
16 citing papers in PubMed.
- Drug Use is Associated with Anti-CD4 IgG-mediated CD4+ T Cell Death and Poor CD4+ T Cell Recovery in Viral-suppressive HIV-infected Individuals Under Antiretroviral Therapy.Current HIV research · 2018Article
- Systemic Immune Activation and HIV Shedding in the Female Genital Tract.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- T-cell activation, both pre- and post-HAART levels, correlates with carotid artery stiffness over 6.5 years among HIV-infected women in the WIHS.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Association of HIV clinical disease progression with profiles of early immune activation: results from a cluster analysis approach.AIDS (London, England) · 2013Article
- An investigation of the possible interaction between the use of Vitamin C and highly active antiretroviral therapy (HAART) adherence and effectiveness in treated HIV+ women.Complementary therapies in medicine · 2012Article
- Permissive and protective factors associated with presence, level, and longitudinal pattern of cervicovaginal HIV shedding.Journal of acquired immune deficiency syndromes (1999) · 2012Article
- HIV infection, immunodeficiency, viral replication, and the risk of cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2011Article
- Relationship between complementary/alternative treatment use and illicit drug use among a cohort of women with, or at risk for, HIV infection.Journal of alternative and complementary medicine (New York, N.Y.) · 2010Article
- Activation of CD8 T cells predicts progression of HIV infection in women coinfected with hepatitis C virus.The Journal of infectious diseases · 2010Article
- CD8(+) T cell activation in women coinfected with human immunodeficiency virus type 1 and hepatitis C virus.The Journal of infectious diseases · 2008Article
- Defective response to Toll-like receptor 3 and 4 ligands by activated monocytes in chronic hepatitis C virus infection.Journal of viral hepatitis · 2008Article
- Illicit drug use, depression and their association with highly active antiretroviral therapy in HIV-positive women.Drug and alcohol dependence · 2007Article
- Presence of hepatitis C virus (HCV) RNA in the genital tracts of HCV/HIV-1-coinfected women.The Journal of infectious diseases · 2005Article
- The Women's Interagency HIV Study: an observational cohort brings clinical sciences to the bench.Clinical and diagnostic laboratory immunology · 2005Review
- The relationship between non-injection drug use behaviors on progression to AIDS and death in a cohort of HIV seropositive women in the era of highly active antiretroviral therapy use.Addiction (Abingdon, England) · 2005Article
- HIV-1 in genital tract and plasma of women: compartmentalization of viral sequences, coreceptor usage, and glycosylation.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The majority of natural history studies of human immunodeficiency virus (HIV) infection have immune and viral parameters in men. Data demonstrating that women have lower HIV-1 RNA levels than men at the same CD4 cell counts have raised the question of immunologic differences in HIV-seropositive women. This study describes levels and changes in phenotypic markers of immune maturity, function, and activation in the CD4 and CD8 cell subsets in HIV-seropositive and high-risk HIV-seronegative women. Our primary hypothesis was that activation levels would be significantly higher among illicit drug users. However, results showed that HIV-1 RNA level was the strongest predictor of marker level and that both HIV-1 RNA level and CD4 cell count were independently associated with CD4 activation, but illicit drug use was not. In summary, this study demonstrated that immune activation was a significant pathogenic feature in women and that activation was driven by HIV infection and not illicit drug use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.