ArticleNucleic acids research2003
Transient recruitment of the hnRNP K protein to inducibly transcribed gene loci.
Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- MSC-Derived Exosomal lnc-AGT-3: A Novel Anti-Angiogenic Target in Age-Related Macular Degeneration Through p53 Signaling Pathway.Aging cell · 2026Article
- The ribonucleoprotein hnRNP K promotes hepatic steatosis by suppressing the nuclear hormone receptor PPARα.The Journal of biological chemistry · 2025Article
- The interferon-regulated host factor hnRNPA0 modulates HIV-1 production by interference with LTR activity, mRNA trafficking, and programmed ribosomal frameshifting.Journal of virology · 2024Article
- SYNCRIP Modulates the Epithelial-Mesenchymal Transition in Hepatocytes and HCC Cells.International journal of molecular sciences · 2022Article
- Circ-GALNT16 restrains colorectal cancer progression by enhancing the SUMOylation of hnRNPK.Journal of experimental & clinical cancer research : CR · 2021Article
- Article
- Role and molecular mechanism of heterogeneous nuclear ribonucleoprotein K in tumor development and progression.Biomedical reports · 2016Article
- Identification and functional characterization of nuclear mortalin in human carcinogenesis.The Journal of biological chemistry · 2014Article
- Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step.The EMBO journal · 2013Article
- Article
- Direct recruitment of ERK cascade components to inducible genes is regulated by heterogeneous nuclear ribonucleoprotein (hnRNP) K.The Journal of biological chemistry · 2011Article
- Higher expression of the heterogeneous nuclear ribonucleoprotein k in melanoma.Annals of surgical oncology · 2010Article
- Dual-function transcription factors and their entourage: unique and unifying themes governing two pathogenesis-related genes.Plant signaling & behavior · 2010Review
- Specification of DNA binding activity of NF-kappaB proteins.Cold Spring Harbor perspectives in biology · 2009Review
- Heterogeneous nuclear ribonucleoprotein K: altered pattern of expression associated with diagnosis and prognosis of prostate cancer.British journal of cancer · 2009Article
- The transcriptional activator Pti4 is required for the recruitment of a repressosome nucleated by repressor SEBF at the potato PR-10a gene.The Plant cell · 2008Article
- Microplate-based chromatin immunoprecipitation method, Matrix ChIP: a platform to study signaling of complex genomic events.Nucleic acids research · 2008Article
- Epistatic interaction between the K-homology domain protein HEK2 and SIR1 at HMR and telomeres in yeast.Journal of molecular biology · 2008Article
- Deciphering the cross talk between hnRNP K and c-Src: the c-Src activation domain in hnRNP K is distinct from a second interaction site.Molecular and cellular biology · 2007Article
- Editing of hnRNP K protein mRNA in colorectal adenocarcinoma and surrounding mucosa.British journal of cancer · 2006Article
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Authors and funding
5 authors.
Funding
Abstract
The heterogeneous nuclear ribonucleoprotein K protein is an RNA- and DNA-binding protein implicated in the regulation of multiple processes that comprise gene expression. We used chromatin immunoprecipitation (ChIP) assays to explore K protein interactions with serum-inducible, constitutively expressed and untranscribed gene loci in vivo. In the rat HTC-IR hepatoma cell line, serum treatment induced transient increases in the mRNA levels of two immediate-early genes, egr-1 and c-myc. ChIP analysis showed that the induction of egr-1 and c-myc genes was associated with a transient recruitment of K protein to multiple sites within each of these loci, including the promoter and transcribed regions. In contrast, recruitment of K protein to the constitutively transcribed beta-actin locus and to randomly chosen non-transcribed loci was far weaker. In rat mesangial cells, c-myc was constitutively expressed while egr-1 remained serum responsive. In these cells, ChIP analysis showed serum-induced recruitment to the inducible egr-1 but not to the c-myc locus. Pre-treatment with the transcription inhibitor actinomycin D blocked the inducible but not the constitutive binding of K protein to these loci. Taken together, the results of this study suggest that the transient recruitment of K protein to serum-responsive loci depends on the inducible transcription of these immediate-early genes.
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