ArticleThe EMBO journal2003
Vertebrate HoxB gene expression requires DNA replication.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 68 citations in OpenAlex.
- Cell cycle-dependent activation of proneural transcription factor expression and reactive gliosis in rat Müller glia.Scientific reports · 2023Article
- Age- and cell cycle-related expression patterns of transcription factors and cell cycle regulators in Müller glia.Scientific reports · 2022Article
- Escape from senescence: revisiting cancer therapeutic strategies.Molecular & cellular oncology · 2022Article
- The shifting shape and functional specializations of the cell cycle during lineage development.WIREs mechanisms of disease · 2021Review
- Global increase in replication fork speed during a p57Science advances · 2017Article
- Effect of overexpression ofOncology letters · 2016Article
- Two distinct modes for propagation of histone PTMs across the cell cycle.Genes & development · 2015Article
- Selective chromatid segregation mechanism invoked for the human congenital mirror hand movement disorder development by RAD51 mutations: a hypothesis.International journal of biological sciences · 2014Review
- Transcriptional response to stress in the dynamic chromatin environment of cycling and mitotic cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- DNA replication-dependent binding of CTCF plays a critical role in adenovirus genome functions.Scientific reports · 2013Article
- Cell-cycle dependence of transcription dominates noise in gene expression.PLoS computational biology · 2013Article
- Multiscale analysis of genome-wide replication timing profiles using a wavelet-based signal-processing algorithm.Nature protocols · 2013Article
- Replication-uncoupled histone deposition during adenovirus DNA replication.Journal of virology · 2012Article
- Chromatin replication and epigenome maintenance.Nature reviews. Molecular cell biology · 2012Review
- Cytomegalovirus replicon-based regulation of gene expression in vitro and in vivo.PLoS pathogens · 2012Article
- Conditional Tet-regulated over-expression of Hoxa2 in CG4 cells increases their proliferation and delays their differentiation into oligodendrocyte-like cells expressing myelin basic protein.Cellular and molecular neurobiology · 2011Article
- Defining the replication program through the chromatin landscape.Critical reviews in biochemistry and molecular biology · 2011Review
- Control of DNA replication by cyclin-dependent kinases in development.Results and problems in cell differentiation · 2011Review
- A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression.PLoS biology · 2010Article
- A link among DNA replication, recombination, and gene expression revealed by genetic and genomic analysis of TEBICHI gene of Arabidopsis thaliana.PLoS genetics · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To study the relationship between DNA replication and transcription in vivo, we investigated Hox gene activation in two vertebrate systems: the embryogenesis of Xenopus and the retinoic acid-induced differentiation of pluripotent mouse P19 cells. We show that the first cell cycles following the mid- blastula transition in Xenopus are necessary and sufficient for HoxB activation, whereas later cell cycles are necessary for the correct expression pattern. In P19 cells, HoxB expression requires proliferation, and the entire locus is activated within one cell cycle. Using synchronous cultures, we found that activation of HoxB genes is colinear within a single cell cycle, occurs during S phase and requires S phase. The HoxB locus replicates early, whereas replication is still required for maximal expression later in S phase. Thus, induction of HoxB genes occurs in a DNA replication-dependent manner and requires only one cell cycle. We propose that S-phase remodelling licenses the locus for transcriptional regulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.