ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
The representation of retinal blood vessels in primate striate cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Saccades orchestrate intraocular glucose dynamics to shape visual responses in birds.Nature communications · 2026Article
- Precise visuotopic organization of the blind spot representation in primate V1.Journal of neurophysiology · 2015Article
- Selective stimulation of penumbral cones reveals perception in the shadow of retinal blood vessels.PloS one · 2015Article
- Macular asymmetry analysis in sighting ocular dominance.The Kaohsiung journal of medical sciences · 2014Article
- Adaptation of the central retina for high acuity vision: cones, the fovea and the avascular zone.Progress in retinal and eye research · 2013Review
- Human trichromacy revisited.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Generalization of learning by synchronous waves: from perceptual organization to invariant organization.Cognitive neurodynamics · 2011Article
- Computational models of spatial updating in peri-saccadic perception.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- Gradients of Eph-A6 expression in primate retina suggest roles in both vascular and axon guidance.Molecular vision · 2009Article
- Plasticity and stability of visual field maps in adult primary visual cortex.Nature reviews. Neuroscience · 2009Review
- Differential gene expression in the developing human macula: microarray analysis using rare tissue samples.Journal of ocular biology, diseases, and informatics · 2009Article
- Ocular dominance columns: enigmas and challenges.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2009Review
- [Not Available].The open ophthalmology journal · 2008Article
- Article
- The effect of angioscotomas on map structure in primary visual cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- On the origin of the functional architecture of the cortex.PloS one · 2007Article
- The cortical column: a structure without a function.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The blood vessels that nourish the inner retina cast shadows on photoreceptors, creating "angioscotomas" in the visual field. We have found the representations of angioscotomas in striate cortex of the squirrel monkey. They were detected in 9 of 12 normal adult animals by staining flatmounts for cytochrome oxidase activity after enucleation of one eye. They appeared as thin profiles in layer 4C radiating from the blind spot representation. Angioscotomas can be regarded as a local form of amblyopia. After birth, when light strikes the retina, photoreceptors beneath blood vessels are denied normal visual stimulation. This deprivation induces remodeling of geniculocortical afferents in a distribution that corresponds to the retinal vascular tree. Angioscotoma representations were most obvious in monkeys with fine ocular dominance columns and were invisible in monkeys with large, well segregated columns. In monkeys without columns, their width corresponded faithfully to the inducing retinal shadow, making it possible to calculate the minimum shadow required to produce a cortical representation. The "amblyogenic threshold" was calculated as the fraction of the pupil area eclipsed to trigger remodeling of geniculocortical afferents. It was found to be constant over retinal eccentricity, vessel size, and shadow size. Ambliogenic shadows only three to four cones wide were sufficient to generate a cortical representation, testifying to the remarkable precision of the cortical map. The representations of retinal blood vessels separated by only 0.65 degrees were resolvable in the cortex, yielding an upper limit on cortical resolution of 340 microm in layer 4C.
Indexed as
Identifiers
12853416PMC6740354W1528768086What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.